Last reviewed 2026-04-20 · How we verify

DermacinRx Surgical ComboPak (COMBO)

At a glance

Approved indications

• surgery or patient care
• bacteria that potentially can cause disease
• diaper rash
• chapped or cracked skin

Common side effects

• Infusion site pain
• Nausea
• Constipation
• Dizziness
• Infusion site extravasation
• Vomiting
• Headache
• Somnolence
• Pruritis
• Hyperhidrosis
• Procedural nausea
• Polyuria

Serious adverse events

• Hepatotoxicity
• Cardiovascular Thrombotic Events
• Gastrointestinal Bleeding, Ulceration, and Perforation
• Hypertension
• Heart Failure and Edema
• Renal Toxicity and Hyperkalemia
• Hypersensitivity and Anaphylactic Reactions
• Exacerbation of Asthma Related to Aspirin Sensitivity
• Serious Skin Reactions
• Drug Rash with Eosinophilia and Systemic Symptoms (DRESS)

Key clinical trials

• Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial (PHASE2)
• A Study of ERAS-007 in Patients With Advanced Gastrointestinal Malignancies (PHASE1,PHASE2)
• A Study to Investigate the Safety and Efficacy of KQB198 as Monotherapy and in Combination in Participants With Advanced Hematologic Malignancies (PHASE1)
• Efficacy and Safety of CHF 1535 200/6µg in Not Adequately Controlled Asthmatic Patients (PHASE3)
• A Study to Evaluate How Pozelimab + Cemdisiran Combination Therapy Works in Adult Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH) Whose Current Treatment is Not Working Efficiently (PHASE3)
• Study of DF1001 in Patients With Advanced Solid Tumors (PHASE1,PHASE2)
• Combination of COMBO Endoscopy Oropharyngeal Airway and HFNC Oxygenation in Sedated Gastrointestinal Endoscopy for Morbidly Obese Patients (NA)
• PhI/II Study of Amivantamab and Tepotinib Combo in MET-altered Non-small Cell Lung Cancer (PHASE1,PHASE2)

Primary sources

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