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Collagen Matrix
Collagen Matrix provides a three-dimensional scaffold that promotes tissue regeneration and wound healing by supporting cell attachment, proliferation, and differentiation.
Collagen Matrix provides a three-dimensional scaffold that promotes tissue regeneration and wound healing by supporting cell attachment, proliferation, and differentiation. Used for Wound healing and tissue regeneration, Surgical applications requiring tissue scaffolding.
At a glance
| Generic name | Collagen Matrix |
|---|---|
| Also known as | Mucograft |
| Sponsor | University of Sao Paulo |
| Drug class | Biomaterial/Tissue scaffold |
| Modality | Small molecule |
| Therapeutic area | Regenerative Medicine/Wound Care |
| Phase | FDA-approved |
Mechanism of action
Collagen Matrix is a biomaterial composed of purified collagen that mimics the extracellular matrix, creating a structural framework for cells to migrate into and populate. It facilitates angiogenesis and tissue remodeling while gradually being resorbed and replaced by native tissue. This approach is commonly used in regenerative medicine and surgical applications to enhance healing of damaged or defective tissues.
Approved indications
- Wound healing and tissue regeneration
- Surgical applications requiring tissue scaffolding
Common side effects
- Inflammatory response
- Infection risk
- Graft rejection or poor integration
Key clinical trials
- Regenerative Collagen Scaffold for Breast Volume Restoration After Breast Cancer Excision (NA)
- Human Repeat Insult Patch Test to Evaluate Skin Irritation and Sensitization in Healthy Volunteers (NA)
- This Study Evaluates Skin Response Following Application of a Collagen-based Material in Healthy Adult Volunteers Using a Standardized Skin Prick Test. Skin Responses Will be Assessed at Multiple Time Points Following Application, and the Study is Intended to Evaluate Dermal Safety. (NA)
- Treatment of Patellofemoral Osteoarthritis With Engineered Cartilage. (PHASE2)
- Implantation of Engineered Cartilage Grafts for Treatment of Patellofemoral Osteoarthritis Versus Surgical Comparators. (PHASE2)
- Biologicals in Management of Intra-Bony Defects (NA)
- Efficacy of a Combined Oral and Topical Collagen Regimen Compared to Topical Collagen or Oral Collagen Regimens in Women With Skin Ageing Signs (NA)
- Intervascular Post-Market Clinical Follow-Up (PMCF) Registry
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |