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Colgate Cavity Protection
Colgate Cavity Protection is a Fluoride toothpaste Small molecule drug developed by GlaxoSmithKline. It is currently FDA-approved for Cavity prevention and caries prophylaxis.
Colgate Cavity Protection uses fluoride to strengthen tooth enamel and prevent dental caries by remineralizing early enamel damage and inhibiting bacterial acid production.
Colgate Cavity Protection uses fluoride to strengthen tooth enamel and prevent dental caries by remineralizing early enamel damage and inhibiting bacterial acid production. Used for Cavity prevention and caries prophylaxis.
At a glance
| Generic name | Colgate Cavity Protection |
|---|---|
| Sponsor | GlaxoSmithKline |
| Drug class | Fluoride toothpaste |
| Target | Tooth enamel hydroxyapatite; oral bacterial metabolism |
| Modality | Small molecule |
| Therapeutic area | Dental/Oral Health |
| Phase | FDA-approved |
Mechanism of action
Fluoride ions are incorporated into the hydroxyapatite crystal structure of tooth enamel, making it more resistant to demineralization by acids produced by oral bacteria. The fluoride also reduces the metabolic activity of cariogenic bacteria, decreasing their ability to produce acids that erode teeth. This dual action—enamel strengthening and bacterial inhibition—reduces cavity formation.
Approved indications
- Cavity prevention and caries prophylaxis
Common side effects
- Dental fluorosis (with excessive ingestion, particularly in children)
- Mild gum irritation or sensitivity
Key clinical trials
- Clinical Study to Assess the Efficacy of New Toothpaste Containing SnF as Compared to Colgate Cavity Protection Toothpaste on the Reduction of Enamel Erosion (PHASE3)
- Investigation of Colgate Dual Zinc Toothpaste as Compared to Colgate Cavity Protection Toothpaste in Controlling Plaque and Gingivitis (PHASE3)
- Hypersensitivity Reduction Efficacy: 5% Potassium Nitrate Toothpaste Compared to Colgate Cavity Protection Toothpaste (PHASE3)
- The Clinical of Stannous Fluoride Toothpaste and a Newly Designed Toothbrush Compared to Colgate Cavity Protection Toothpaste and a Regular Toothbrush in Reducing Plaque and Gingivitis. (PHASE3)
- Dentinal Hypersensitivity Reduction Efficacy Study (PHASE3)
- Clinical Investigation of PerioGard (Test) Regimen (PHASE3)
- A Study to Evaluate the Efficacy of a Stannous Fluoride Toothpaste With a Cetylpyridinium Chloride Mouthwash in Improving Gingival Health and Reducing Plaque Accumulation (NA)
- Fluoride in Saliva After Use of Fluoride Toothpastes Followed by Fluoride Mouthrinses (EARLY_PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Colgate Cavity Protection CI brief — competitive landscape report
- Colgate Cavity Protection updates RSS · CI watch RSS
- GlaxoSmithKline portfolio CI
Frequently asked questions about Colgate Cavity Protection
What is Colgate Cavity Protection?
How does Colgate Cavity Protection work?
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What development phase is Colgate Cavity Protection in?
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What does Colgate Cavity Protection target?
Related
- Drug class: All Fluoride toothpaste drugs
- Target: All drugs targeting Tooth enamel hydroxyapatite; oral bacterial metabolism
- Manufacturer: GlaxoSmithKline — full pipeline
- Therapeutic area: All drugs in Dental/Oral Health
- Indication: Drugs for Cavity prevention and caries prophylaxis
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing