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Colchicine (for 6 months)
Colchicine inhibits microtubule polymerization by binding to tubulin, thereby suppressing inflammatory cell migration and reducing production of inflammatory mediators.
Colchicine inhibits microtubule polymerization by binding to tubulin, thereby suppressing inflammatory cell migration and reducing production of inflammatory mediators. Used for Acute gout flares, Gout prophylaxis, Familial Mediterranean fever.
At a glance
| Generic name | Colchicine (for 6 months) |
|---|---|
| Sponsor | Azienda Sanitaria Locale 3, Torino |
| Drug class | Microtubule inhibitor / Anti-inflammatory agent |
| Target | Tubulin (alpha and beta subunits) |
| Modality | Small molecule |
| Therapeutic area | Immunology / Cardiovascular / Rheumatology |
| Phase | Phase 3 |
Mechanism of action
Colchicine disrupts microtubule dynamics, which impairs the movement and activation of neutrophils and other immune cells. This leads to decreased secretion of pro-inflammatory cytokines and chemokines, reducing the inflammatory cascade. The drug has been used for decades in gout and is being investigated for its anti-inflammatory effects in various cardiovascular and inflammatory conditions.
Approved indications
- Acute gout flares
- Gout prophylaxis
- Familial Mediterranean fever
- Pericarditis (investigational)
Common side effects
- Diarrhea
- Nausea
- Abdominal pain
- Myopathy
- Neutropenia
- Elevated liver enzymes
Key clinical trials
- A Randomized Multicenter Study for Isolated Skin Vasculitis (PHASE2)
- Treat-to-Target Serum Urate Versus Treat-to-Avoid Symptoms in Gout (PHASE4)
- is There an Effect of Adding Body Vibration to Intake of Vitamin D on Some Outcomes of Familial Mediterranean Fever (NA)
- Mediterranean Diet in Familial Mediterranean Fever: Is Fatty Liver Affected by Addition of Aerobic Exercise (NA)
- A Study to Evaluate Efficacy and Safety of Anakinra in Chinese Patients With Colchicine-resistent FMF (PHASE4)
- CMP-MYTHiC Trial and Registry - CardioMyoPathy With MYocarditis THerapy With Colchicine (PHASE3)
- Effect of Colchicine on the Progression of Aortic Valve Stenosis - a Pilot Study (PHASE2, PHASE3)
- Study of Pegloticase (KRYSTEXXA®) Plus Methotrexate in Patients With Uncontrolled Gout (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |