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Codeine + Diclofenac
This combination product pairs an opioid analgesic (codeine) with a nonsteroidal anti-inflammatory drug (diclofenac) to provide synergistic pain relief through different mechanisms.
This combination product pairs an opioid analgesic (codeine) with a nonsteroidal anti-inflammatory drug (diclofenac) to provide synergistic pain relief through different mechanisms. Used for Moderate acute and chronic pain, Post-operative pain, Musculoskeletal pain.
At a glance
| Generic name | Codeine + Diclofenac |
|---|---|
| Also known as | Lower third molar surgery, Pain control, NSAID associated with Opioids |
| Sponsor | University of Sao Paulo |
| Drug class | Opioid + NSAID combination analgesic |
| Target | Mu opioid receptor (codeine); COX-1 and COX-2 (diclofenac) |
| Modality | Small molecule |
| Therapeutic area | Pain Management |
| Phase | FDA-approved |
Mechanism of action
Codeine is a weak opioid agonist that binds to mu opioid receptors in the central nervous system to reduce pain perception. Diclofenac is a nonselective COX inhibitor that reduces prostaglandin synthesis, decreasing inflammation and pain at the peripheral level. Together, they provide enhanced analgesia for moderate pain conditions.
Approved indications
- Moderate acute and chronic pain
- Post-operative pain
- Musculoskeletal pain
Common side effects
- Nausea
- Dizziness
- Constipation
- Gastrointestinal upset
- Drowsiness
- Dyspepsia
Key clinical trials
- Effects of an Opioid Free/Sparing Care Pathway for Patients Undergoing Obesity Surgery (NA)
- Effectiveness of Conventional Therapy Plus Pulsed-Radiofrequency for Herniated Nucleus Pulposus (NA)
- An Randomized Control Trial Comparing Two Drug Combinations for Pain Management After Third Molars Surgery (NA)
- COMPARISON OF EFFICACY OF DIFFERENT DRUG COMBINATIONS IN ACUTE SCIATICA (PHASE3)
- Battlefield Acupuncture for Acute/Subacute Back Pain in the Emergency Department (NA)
- Operative Treatment of Unstable Thoracic Cage Injuries and Chest Wall Deformity in Trauma (NA)
- Pain as Indication for Operative Treatment of Traumatic Rib Fractures (NA)
- To Compare the Efficacy and Patients' Satisfaction for the Treatment of Post Cesarean Pain of Two Protocols: Oral Medications in Fixed Time Interval Administration Versus Spinal Morphine (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |