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clonidine, levobupivacaine
Clonidine is an alpha-2 adrenergic agonist that reduces pain signaling, while levobupivacaine is a local anesthetic that blocks sodium channels to prevent nerve conduction.
Clonidine is an alpha-2 adrenergic agonist that reduces pain signaling, while levobupivacaine is a local anesthetic that blocks sodium channels to prevent nerve conduction. Used for Regional anesthesia and analgesia for surgical procedures, Postoperative pain management.
At a glance
| Generic name | clonidine, levobupivacaine |
|---|---|
| Also known as | clonidine [Catapres®, Boehringer Ingelheim, Germany], levobupivacaine [Chirocaine®, Abbott S.p.A., Italy] |
| Sponsor | University Hospital Dubrava |
| Drug class | Local anesthetic with adjuvant alpha-2 agonist |
| Target | Alpha-2 adrenergic receptor (clonidine); voltage-gated sodium channels (levobupivacaine) |
| Modality | Small molecule |
| Therapeutic area | Anesthesia and Pain Management |
| Phase | FDA-approved |
Mechanism of action
This combination is used for regional anesthesia and analgesia. Clonidine enhances the analgesic effect of the local anesthetic by activating alpha-2 adrenergic receptors in the spinal cord and peripheral nerves, reducing pain transmission. Levobupivacaine, the active S-enantiomer of bupivacaine, blocks voltage-gated sodium channels in nerve fibers, preventing action potential propagation and producing local anesthesia.
Approved indications
- Regional anesthesia and analgesia for surgical procedures
- Postoperative pain management
Common side effects
- Hypotension
- Bradycardia
- Sedation
- Dry mouth
- Dizziness
- Nausea
Key clinical trials
- Effectiveness of TAP Block Versus Intravenous Analgesia in Postoperative Pain Management Following Gynecologic Laparoscopic Surgery
- Pulsed Radiofrequency Therapy vs Canal Adductor Blockade in Knee Osteoarthritis
- The Effect of Local Anesthetic and Clonidine on the Cutaneous Silent Period During Spinal Anesthesia (PHASE4)
- Effectivness of Tramadol or Topic Lidocaine on Postoperative Analgesia in Laparoscopic Colorectal Resection. (NA)
- Interest in Clonidine in Association With Levobupivacaine Performing a Pudendal Block in Proctological Surgery. (PHASE4)
- Dexmedetomidine Versus Clonidine in TAP Block (PHASE2, PHASE3)
- Interest of a Bi-truncal Nerve Block (Femoral + Sciatic) Extended, Systematically Associated With General Anesthesia, in the Femoropopliteal Bypass: Study of Post-operative Analgesia and Peripheral Circulation Downstream (PHASE4)
- Programmed Intermittent Epidural Bolus Versus Continuous Epidural Infusion for Third Trimester Medical Termination of Pregnancy Analgesia : a Randomized Study. (PCEA-IMG) (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- clonidine, levobupivacaine CI brief — competitive landscape report
- clonidine, levobupivacaine updates RSS · CI watch RSS
- University Hospital Dubrava portfolio CI