Last reviewed 2026-04-22 · How we verify

Cloderm Cream

Cloderm Cream is a topical corticosteroid that reduces inflammation and suppresses immune responses in the skin.

Cloderm Cream is a topical corticosteroid that reduces inflammation and suppresses immune responses in the skin. Used for Inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses, Atopic dermatitis, Contact dermatitis.

At a glance

Mechanism of action

Cloderm contains clocortolone pivalate, a mid-potency corticosteroid that binds to glucocorticoid receptors in skin cells, reducing the production of inflammatory mediators and suppressing T-cell activation. This leads to decreased inflammation, itching, and other signs of dermatitis when applied topically.

Approved indications

• Inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses
• Atopic dermatitis
• Contact dermatitis
• Seborrheic dermatitis

Common side effects

• Skin irritation or burning
• Pruritus
• Skin atrophy (with prolonged use)
• Folliculitis

Key clinical trials

• Bio-equivalence Vasoconstriction Activity Study for Topically Applied Clocortolone Pivalate 0.1% Cream (PHASE1)
• Study of the Efficacy of Cloderm® Cream in the Treatment of Moderate Plaque Psoriasis (PHASE4)

Primary sources

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Competitive intelligence

For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:

• Cloderm Cream CI brief — competitive landscape report
• Cloderm Cream updates RSS · CI watch RSS
• Promius Pharma, LLC portfolio CI