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clobetasol propionate alone
Clobetasol propionate is a potent topical corticosteroid that suppresses inflammatory and immune responses in the skin by binding to glucocorticoid receptors.
Clobetasol propionate is a potent topical corticosteroid that suppresses inflammatory and immune responses in the skin by binding to glucocorticoid receptors. Used for Inflammatory and pruritic dermatoses responsive to topical corticosteroids (e.g., psoriasis, lichen planus, severe eczema), Alopecia areata.
At a glance
| Generic name | clobetasol propionate alone |
|---|---|
| Sponsor | University Hospital, Montpellier |
| Drug class | Topical corticosteroid (Class I/super-potent) |
| Target | Glucocorticoid receptor |
| Modality | Small molecule |
| Therapeutic area | Dermatology |
| Phase | Phase 3 |
Mechanism of action
Clobetasol propionate is a Class I (super-potent) corticosteroid that works by activating intracellular glucocorticoid receptors, leading to decreased production of inflammatory cytokines, reduced immune cell infiltration, and suppression of local inflammatory cascades. This results in rapid reduction of erythema, pruritus, and other inflammatory skin manifestations. The drug is applied topically and acts locally at the site of inflammation.
Approved indications
- Inflammatory and pruritic dermatoses responsive to topical corticosteroids (e.g., psoriasis, lichen planus, severe eczema)
- Alopecia areata
Common side effects
- Skin atrophy
- Striae
- Telangiectasia
- Systemic corticosteroid absorption (with prolonged use or occlusion)
- Local irritation or burning
Key clinical trials
- Comparison of Laser Treatment With Clobetasol Therapy in Patients With Lichen Sclerosus (NA)
- ZINCLO-HAND: Zinc and Clobetasol for the Prevention of Regorafenib-Induced Hand-Foot Skin Reaction (NA)
- Does Steroid Plus CO2 Laser Improve Lichen Sclerosus Symptoms Compared to Steroids Alone? (PHASE2, PHASE3)
- A Single-Centre Clinical Trial to Assess Steroid Induced Skin Atrophy on Healthy Skin (PHASE1)
- A Psoriasis Plaque Test Comparing Products for the Treatment of Psoriasis Vulgaris (PHASE1)
- Assess the Potential for Adrenal Suppression and Systemic Drug Absorption Following Multiple Dosing With DFD-06 (PHASE2)
- Direct Diagnosis of Disseminated Lyme Borreliosis. (NA)
- Topical Steroids Alone or Associated With Methotrexate in Bullous Pemphigoid (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- clobetasol propionate alone CI brief — competitive landscape report
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- University Hospital, Montpellier portfolio CI