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Clobetasol Ointment
Clobetasol Ointment is a Topical corticosteroid (Class I/super-potent) Small molecule drug developed by National Institute of Allergy and Infectious Diseases (NIAID). It is currently FDA-approved for Inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses, Psoriasis, Eczema. Also known as: Clobex spray, Mucoadhesive Clobetasol Patch, Dermovate.
Clobetasol propionate is a potent topical corticosteroid that suppresses inflammatory and immune responses in the skin by binding to glucocorticoid receptors.
Clobetasol propionate is a potent topical corticosteroid that suppresses inflammatory and immune responses in the skin by binding to glucocorticoid receptors. Used for Inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses, Psoriasis, Eczema.
At a glance
| Generic name | Clobetasol Ointment |
|---|---|
| Also known as | Clobex spray, Mucoadhesive Clobetasol Patch, Dermovate |
| Sponsor | National Institute of Allergy and Infectious Diseases (NIAID) |
| Drug class | Topical corticosteroid (Class I/super-potent) |
| Target | Glucocorticoid receptor |
| Modality | Small molecule |
| Therapeutic area | Dermatology |
| Phase | FDA-approved |
Mechanism of action
Clobetasol propionate is a Class I (super-potent) corticosteroid that works by activating intracellular glucocorticoid receptors, leading to decreased production of inflammatory mediators, reduced immune cell infiltration, and suppression of local inflammatory responses. It reduces erythema, pruritus, and other signs of skin inflammation through these anti-inflammatory and immunosuppressive mechanisms.
Approved indications
- Inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses
- Psoriasis
- Eczema
- Lichen planus
- Vitiligo (adjunctive)
Common side effects
- Skin atrophy
- Striae
- Telangiectasia
- Folliculitis
- Hypertrichosis
- Acneiform eruptions
- Hypopigmentation
- Secondary infection
Key clinical trials
- Clinical Trial to Demonstrate That the Dual Laser Therapy is Effective for the Treatment of Vulvar Lichen Sclerosus (NA)
- Targeted Investigation of Microbiome 2 Treat Atopic Dermatitis (TIME-2) (PHASE1)
- Effectiveness of Micro-needling With 5 Fluorouracil Versus Potent Topical Steroids in the Treatment of Limited Vitiligo (EARLY_PHASE1)
- To Compare Inflammatory Biomarkers Before and After Treatment With Clobetasol or Fractional CO2 Laser, in Women With Histologically Confirmed Vulvar Lichen Sclerosus, Without Prior Corticosteroid Treatment. (NA)
- Early Intervention in Plaque Psoriasis: is Bimekizumab Able to Delay Chronic Inflammation? (PHASE2)
- Treatment of Vulvar Lichen Sclerosus With Corticosteroid Ointment, Calcineurin Inhibitor Ointment, and Platelet-Rich Plasma (PRP) Therapy. (NA)
- Fractionated CO2 Laser With and Without Clobetasol for Treatment of Vulvar Lichen Sclerosus (PHASE4)
- A Clinical Trial to Assess the Potential of LEO 130852A Gel to Reduce Steroid Induced Skin Atrophy on Healthy Skin (PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Clobetasol Ointment CI brief — competitive landscape report
- Clobetasol Ointment updates RSS · CI watch RSS
- National Institute of Allergy and Infectious Diseases (NIAID) portfolio CI
Frequently asked questions about Clobetasol Ointment
What is Clobetasol Ointment?
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What is Clobetasol Ointment used for?
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Is Clobetasol Ointment also known as anything else?
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What does Clobetasol Ointment target?
Related
- Drug class: All Topical corticosteroid (Class I/super-potent) drugs
- Target: All drugs targeting Glucocorticoid receptor
- Manufacturer: National Institute of Allergy and Infectious Diseases (NIAID) — full pipeline
- Therapeutic area: All drugs in Dermatology
- Indication: Drugs for Inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses
- Indication: Drugs for Psoriasis
- Indication: Drugs for Eczema
- Also known as: Clobex spray, Mucoadhesive Clobetasol Patch, Dermovate
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing