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Clindamycin + Gentamicin
Clindamycin and gentamicin are a combination antibiotic therapy that inhibits bacterial protein synthesis through different mechanisms to provide broad-spectrum coverage against aerobic and anaerobic pathogens.
Clindamycin and gentamicin are a combination antibiotic therapy that inhibits bacterial protein synthesis through different mechanisms to provide broad-spectrum coverage against aerobic and anaerobic pathogens. Used for Polymicrobial infections including intra-abdominal infections, Gynecological infections, Respiratory tract infections with mixed aerobic and anaerobic pathogens.
At a glance
| Generic name | Clindamycin + Gentamicin |
|---|---|
| Also known as | Cleocin + Garamycin |
| Sponsor | Mercy Health Ohio |
| Drug class | Antibiotic combination (lincosamide + aminoglycoside) |
| Target | Bacterial ribosome (50S subunit for clindamycin; 30S subunit for gentamicin) |
| Modality | Small molecule |
| Therapeutic area | Infectious Disease |
| Phase | FDA-approved |
Mechanism of action
Clindamycin is a lincosamide that binds to the bacterial 50S ribosomal subunit to inhibit protein synthesis, with particular activity against anaerobes and gram-positive organisms. Gentamicin is an aminoglycoside that binds to the 30S ribosomal subunit and inhibits protein synthesis, providing coverage against aerobic gram-negative bacteria and some gram-positive organisms. Together, they provide synergistic coverage for polymicrobial infections.
Approved indications
- Polymicrobial infections including intra-abdominal infections
- Gynecological infections
- Respiratory tract infections with mixed aerobic and anaerobic pathogens
Common side effects
- Diarrhea (clindamycin-associated)
- Nephrotoxicity (gentamicin-related)
- Ototoxicity (gentamicin-related)
- Pseudomembranous colitis
- Hypersensitivity reactions
Key clinical trials
- Dual vs. Single-Antibiotic Impregnated Cement in Hemiarthroplasty for Femoral Neck Fracture (PHASE3)
- Use of Antibiotic Irrigation to Decrease Wound Infections in Pediatric Perforated Appendicitis (PHASE2)
- Antibiotic Prophylaxis in Patients Undergoing Elective Total Knee Arthroplasty- Multi-center Trial (PHASE4)
- Clindamycin Once a Day in Septic Abortion (PHASE4)
- Refobacin Revision-3 Bone Cement Post-Market Study
- TAILORED Therapeutic Regime in Patients With Preterm Premature Rupture Of Membranes to Prolong Pregnancy, Improve Maternal and Neonatal Outcomes, and Reduce Antibiotic Burden (PHASE3)
- Treatment of Chorioamnionitis After Delivery (NA)
- Laparoscopic Antibiotic Lavage to Prevent Intra-abdominal Abscess Formation in Complicated Appendicitis (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Clindamycin + Gentamicin CI brief — competitive landscape report
- Clindamycin + Gentamicin updates RSS · CI watch RSS
- Mercy Health Ohio portfolio CI