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CitraFleet

Norgine · FDA-approved active Small molecule

CitraFleet is an osmotic laxative bowel preparation that draws water into the colon to promote evacuation and cleanse the bowel.

CitraFleet is an osmotic laxative bowel preparation that draws water into the colon to promote evacuation and cleanse the bowel. Used for Bowel cleansing prior to colonoscopy, Bowel cleansing prior to barium enema or other radiological examination of the colon.

At a glance

Generic nameCitraFleet
SponsorNorgine
Drug classOsmotic laxative bowel preparation
ModalitySmall molecule
Therapeutic areaGastroenterology
PhaseFDA-approved

Mechanism of action

CitraFleet combines sodium picosulfate (a stimulant laxative) with magnesium citrate (an osmotic agent) to produce rapid bowel evacuation. The sodium picosulfate stimulates colonic contractions while the magnesium citrate creates an osmotic gradient that draws fluid into the intestinal lumen, resulting in thorough bowel cleansing without significant fluid and electrolyte depletion.

Approved indications

Common side effects

Key clinical trials

Primary sources

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SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results