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Cisplatin and Docetaxel
Cisplatin and docetaxel work together as a chemotherapy combination: cisplatin cross-links DNA to prevent replication, while docetaxel stabilizes microtubules to disrupt cell division.
Cisplatin and docetaxel work together as a chemotherapy combination: cisplatin cross-links DNA to prevent replication, while docetaxel stabilizes microtubules to disrupt cell division. Used for Non-small cell lung cancer, Head and neck cancer, Gastric cancer.
At a glance
| Generic name | Cisplatin and Docetaxel |
|---|---|
| Also known as | TP, radiation, enteral nutrition and parenteral nutrition |
| Sponsor | Swiss Cancer Institute |
| Drug class | Chemotherapy combination (platinum agent + taxane) |
| Target | DNA (cisplatin); beta-tubulin (docetaxel) |
| Modality | Small molecule |
| Therapeutic area | Oncology |
| Phase | Phase 3 |
Mechanism of action
Cisplatin is a platinum-based alkylating agent that forms covalent bonds with DNA, preventing strand separation and triggering apoptosis in cancer cells. Docetaxel is a taxane that binds to beta-tubulin and prevents microtubule depolymerization, halting mitosis. The combination exploits complementary mechanisms to enhance cytotoxic effects against rapidly dividing cancer cells.
Approved indications
- Non-small cell lung cancer
- Head and neck cancer
- Gastric cancer
- Ovarian cancer
Common side effects
- Neutropenia
- Anemia
- Thrombocytopenia
- Nausea and vomiting
- Peripheral neuropathy
- Alopecia
- Mucositis
- Nephrotoxicity
Key clinical trials
- Becotatug Vedotin for LA-NPC With a Suboptimal Response to Induction Chemotherapy Combined With Immunotherapy (PHASE2)
- Phase II Trial of Neoadjuvant Chemotherapy (NAC) Alone or in Combination With Immunotherapy Vaccine PRGN-2009 in Subjects With Newly Diagnosed HPV-Associated Oropharyngeal (Head and Neck) Cancer (PHASE2)
- Testing the Use of Investigational Drugs Atezolizumab and/or Bevacizumab With or Without Standard Chemotherapy in the Second-Line Treatment of Advanced-Stage Head and Neck Cancers (PHASE2, PHASE3)
- A Study Comparing the Combination of Pembrolizumab and Sacituzumab Govitecan Versus Standard of Care in the Treatment of Advanced Urothelial Cancer (PHASE3)
- Chemotherapy Before Surgery and Radiation Therapy or Surgery and Radiation Therapy Alone in Treating Patients With Nasal and Paranasal Sinus Cancer That Can Be Removed by Surgery (PHASE2)
- Durvalumab in Combination With Docetaxel, Cisplatin and 5-FU for Locally Advanced Head and Neck Squamous Cell Carcinoma (PHASE1)
- Immunotherapy With Chemotherapy and Chemoradiation for Advanced Squamous Cancer of Nasal Cavity / Paranasal Sinuses (I-NAPA) (PHASE2)
- A Real-world Study of Characteristics, Treatment Patterns, and Clinical Outcomes Among Lutetium-177 Vipivotide Tetraxetan Treated Patients
Primary sources
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| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |