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ciprofloxacin, cotrimoxazole-trimethoprim, macrodantin
ciprofloxacin, cotrimoxazole-trimethoprim, macrodantin is a Fluoroquinolone, Sulfonamide-diaminopyrimidine combination, Nitrofuran Small molecule drug developed by University of British Columbia. It is currently FDA-approved for Urinary tract infections, Bacterial respiratory infections, Gastrointestinal infections. Also known as: Keflex, Macrobid, co-trimoxazole.
This is a combination of three distinct antibacterial agents that work through different mechanisms to inhibit bacterial growth and kill bacteria.
This is a combination of three distinct antibacterial agents that work through different mechanisms to inhibit bacterial growth and kill bacteria. Used for Urinary tract infections, Bacterial respiratory infections, Gastrointestinal infections.
At a glance
| Generic name | ciprofloxacin, cotrimoxazole-trimethoprim, macrodantin |
|---|---|
| Also known as | Keflex, Macrobid, co-trimoxazole |
| Sponsor | University of British Columbia |
| Drug class | Fluoroquinolone, Sulfonamide-diaminopyrimidine combination, Nitrofuran |
| Target | Bacterial DNA gyrase, topoisomerase IV, dihydrofolate reductase, bacterial DNA |
| Modality | Small molecule |
| Therapeutic area | Infectious Disease |
| Phase | FDA-approved |
Mechanism of action
Ciprofloxacin is a fluoroquinolone that inhibits bacterial DNA gyrase and topoisomerase IV, preventing DNA replication. Cotrimoxazole (sulfamethoxazole-trimethoprim) is a sulfonamide-diaminopyrimidine combination that sequentially blocks bacterial folate synthesis. Nitrofurantoin (macrodantin) generates reactive oxygen species that damage bacterial DNA and proteins. Together, these agents provide broad-spectrum coverage against gram-positive and gram-negative bacteria.
Approved indications
- Urinary tract infections
- Bacterial respiratory infections
- Gastrointestinal infections
- Skin and soft tissue infections
Common side effects
- Nausea
- Diarrhea
- Headache
- Photosensitivity (ciprofloxacin)
- Rash
- Peripheral neuropathy (nitrofurantoin)
- Stevens-Johnson syndrome (rare)
Key clinical trials
- Role of Prophylactic Postoperative Antibiotics in HoLEP (PHASE4)
- Randomized Trial of Culture Directed Versus Empiric Antibiotics for Urinary Tract Infections in Older Women (PHASE4)
- Endourology Disease Group Excellence (EDGE) Consortium: Antibiotics (Abx) for Percutaneous Nephrolithotomy (PCNL) Part 2 (NA)
- Clinical Trial Testing Whether Targeted Antibiotic Prophylaxis Can Reduce Infections After Cystectomy Compared to Empiric Prophylaxis (PHASE4)
- Use of Prophylactic Antibiotics Prior to OnabotulinumtoxinA (PHASE4)
- Prophylactic Antibiotic Administration for Bladder OnabotulinumtoxinA Injection (PHASE4)
- Enhanced Versus Extended Preoperative Antibiotic Prophylaxis Regimens for Retrograde Intrarenal Surgery in High Infectious Risk Patients (PHASE3)
- Struvite Stones Antibiotic Study (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- ciprofloxacin, cotrimoxazole-trimethoprim, macrodantin CI brief — competitive landscape report
- ciprofloxacin, cotrimoxazole-trimethoprim, macrodantin updates RSS · CI watch RSS
- University of British Columbia portfolio CI
Frequently asked questions about ciprofloxacin, cotrimoxazole-trimethoprim, macrodantin
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Is ciprofloxacin, cotrimoxazole-trimethoprim, macrodantin also known as anything else?
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Related
- Drug class: All Fluoroquinolone, Sulfonamide-diaminopyrimidine combination, Nitrofuran drugs
- Target: All drugs targeting Bacterial DNA gyrase, topoisomerase IV, dihydrofolate reductase, bacterial DNA
- Manufacturer: University of British Columbia — full pipeline
- Therapeutic area: All drugs in Infectious Disease
- Indication: Drugs for Urinary tract infections
- Indication: Drugs for Bacterial respiratory infections
- Indication: Drugs for Gastrointestinal infections
- Also known as: Keflex, Macrobid, co-trimoxazole
- Compare: ciprofloxacin, cotrimoxazole-trimethoprim, macrodantin vs similar drugs
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