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Chorionic Gonadotropin
Chorionic gonadotropin (hCG) mimics luteinizing hormone to stimulate testosterone production in males and support progesterone production in females during pregnancy.
Chorionic gonadotropin (hCG) mimics luteinizing hormone to stimulate testosterone production in males and support progesterone production in females during pregnancy. Used for Female infertility (ovulation induction in assisted reproductive technology), Male hypogonadism and infertility (testosterone stimulation), Pregnancy support (luteal phase support).
At a glance
| Generic name | Chorionic Gonadotropin |
|---|---|
| Also known as | choriomon |
| Sponsor | El Shatby University Hospital for Obstetrics and Gynecology |
| Drug class | Gonadotropin |
| Target | Luteinizing hormone receptor (LH receptor) |
| Modality | Small molecule |
| Therapeutic area | Reproductive/Fertility |
| Phase | FDA-approved |
Mechanism of action
Chorionic gonadotropin is a glycoprotein hormone that binds to luteinizing hormone receptors on Leydig cells (in males) and corpus luteum cells (in females). In males, it stimulates testosterone synthesis and spermatogenesis. In females, it maintains progesterone secretion during early pregnancy, preventing corpus luteum regression and supporting pregnancy continuation.
Approved indications
- Female infertility (ovulation induction in assisted reproductive technology)
- Male hypogonadism and infertility (testosterone stimulation)
- Pregnancy support (luteal phase support)
Common side effects
- Ovarian hyperstimulation syndrome (OHSS)
- Headache
- Injection site reactions
- Abdominal pain/bloating
- Nausea
Key clinical trials
- Ruxolitinib, Human Chorionic Gonadotropin (uhCG/EGF), and Dose De-escalated Corticosteroids (PHASE1, PHASE2)
- INTEnsity of ovariaN Stimulation and Embryo Quality (PHASE4)
- Impact Of FET Preparation Protocol On Endometrial Peristalsis: A Prospective Cohort Study
- Isotretinoin vs hCG for Male Infertility Due to Low or Absent Sperm (PHASE2)
- Study of Different Therapeutic Strategies in Hydatidiform Mole With Lung Nodule (NA)
- Assessment of the Feasibility of Frozen Embryo Transfers in a Natural Cycle Among Obese Compared to Non-Obese Patients
- PTCY Plus uhCG/EGF for Graft Versus Host Disease Prophylaxis (PHASE1)
- Assessing the Convenience of Natural Proliferative Phase Frozen Embryo Transfer
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |