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Cholecalciferol Pill
Cholecalciferol (vitamin D3) is converted in the body to its active form, calcitriol, which regulates calcium and phosphate homeostasis and supports bone mineralization.
Cholecalciferol (vitamin D3) is converted in the body to its active form, calcitriol, which regulates calcium and phosphate homeostasis and supports bone mineralization. Used for Vitamin D deficiency, Rickets, Osteomalacia.
At a glance
| Generic name | Cholecalciferol Pill |
|---|---|
| Sponsor | Hospital Infantil de Mexico Federico Gomez |
| Drug class | Vitamin D supplement |
| Target | Vitamin D receptor (VDR) |
| Modality | Small molecule |
| Therapeutic area | Nutritional/Metabolic |
| Phase | FDA-approved |
Mechanism of action
Cholecalciferol is a fat-soluble vitamin that undergoes hydroxylation in the liver and kidneys to form the active hormone calcitriol (1,25-dihydroxyvitamin D3). Calcitriol acts as a ligand for the vitamin D receptor (VDR), a nuclear receptor that regulates intestinal calcium and phosphate absorption, renal calcium reabsorption, and bone mineralization. This mechanism is essential for maintaining serum calcium and phosphate levels and supporting skeletal health.
Approved indications
- Vitamin D deficiency
- Rickets
- Osteomalacia
- Hypoparathyroidism
- Nutritional supplementation in pediatric populations
Common side effects
- Hypercalcemia
- Hypercalciuria
- Nausea
- Vomiting
- Constipation
Key clinical trials
- Acute Vitamin D Supplementation on Testosterone in Females (NA)
- Impact of Vitamin D Supplementation on the Rate of Pathologic Complete Response in Vitamin D Deficient Patients (PHASE2)
- Assessment of Medrol Dosepak to Reduce Opioid Consumption in Foot and Ankle Surgical Patients (PHASE2)
- Alii Supplement Study (PHASE2)
- Vitamin D Homeostasis in Sarcoidosis (PHASE4)
- Effects of Laser Therapy and Vitamin D Pills on Braces Tooth Movement: A Random Controlled Study (NA)
- Vitamin D and Fish Oil for Autoimmune Disease, Inflammation and Knee Pain (NA)
- Bioavailability of Vitamin D(25(OH)D) and Omega-3 Fatty Acid (DHA) Enhanced Chicken
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Cholecalciferol Pill CI brief — competitive landscape report
- Cholecalciferol Pill updates RSS · CI watch RSS
- Hospital Infantil de Mexico Federico Gomez portfolio CI