Last reviewed · How we verify
Chloroprocaine HCl 2%
Chloroprocaine HCl is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses.
Chloroprocaine HCl is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses. Used for Local anesthesia for infiltration, nerve block, and epidural anesthesia.
At a glance
| Generic name | Chloroprocaine HCl 2% |
|---|---|
| Also known as | Ampres |
| Sponsor | Sintetica SA |
| Drug class | Local anesthetic (ester) |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | Phase 3 |
Mechanism of action
As an ester-type local anesthetic, chloroprocaine works by inhibiting sodium influx through voltage-gated sodium channels in neuronal membranes, thereby stabilizing the membrane and preventing depolarization. This action reversibly blocks the generation and propagation of action potentials in sensory, motor, and autonomic nerve fibers. The drug is rapidly metabolized by plasma pseudocholinesterase, resulting in a short duration of action.
Approved indications
- Local anesthesia for infiltration, nerve block, and epidural anesthesia
Common side effects
- Nervousness or anxiety
- Dizziness or lightheadedness
- Tremor
- Allergic reactions (rare)
- Methemoglobinemia (with high doses)
Key clinical trials
- The Efficacy and Safety of Chloroprocaine 1% and 2% in Pediatric Population (PHASE2)
- Efficacy and Safety of Chloroprocaine 3% Gel and Oxybuprocaine 0.4% Eye Drops Anesthesia in Pediatric Population (PHASE3)
- Study Evaluating the Efficacy and Safety of Chloroprocaine HCl Ophthalmic Gel 3% vs Proparacaine Ophthalmic Solution 0.5% Plus Subconjunctival Lidocaine in Patients Undergoing Intravitreal Injections (PHASE4)
- Targeted Nerve Injection to the Knee (Nerve to Vastus Medialis): Comparing Two Adductor Canal Block Approaches (PHASE4)
- Chloroprocaine Lavage to Improve Outcomes Related to Operative Cesarean Delivery (EARLY_PHASE1)
- Mechanisms and Treatment of Post-amputation Neuropathic Pain (NA)
- Chloroprocaine 3% - Epidural Anesthesia in Unplanned Caesarean Section (PHASE3)
- Trial Comparing the Onset and Duration of Ultrasound Guided Supraclavicular Nerve Blocks Using Ropivacaine Versus Ropivacaine-Chloroprocaine Mixture (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Chloroprocaine HCl 2% CI brief — competitive landscape report
- Chloroprocaine HCl 2% updates RSS · CI watch RSS
- Sintetica SA portfolio CI