Last reviewed 2026-04-23 · How we verify

chlorhexidine/lidocaine

Chlorhexidine/lidocaine is a topical antiseptic and local anesthetic combination.

Chlorhexidine/lidocaine is a topical antiseptic and local anesthetic combination. Used for Prevention of infection in minor surgical procedures.

At a glance

Mechanism of action

Chlorhexidine is a disinfectant that kills bacteria and other microorganisms, while lidocaine is a local anesthetic that numbs the skin and mucous membranes. This combination is used to prevent infection and provide pain relief in various medical procedures.

Approved indications

• Prevention of infection in minor surgical procedures

Common side effects

• Skin irritation

Key clinical trials

• Evaluation of Percutaneous Cryoneurotomy Compared to Surgical Open Neurotomy for the Management of Equinovarus Foot Deformity in Patients With Refractory Lower Limb Spasticity After Stroke (NA)
• Intrathecal MoRphine Versus Transabdominal Plane Block (TAP) Block for AnalGesic Management in Elective Caesarean Section (PHASE4)
• A Phase 1/2 Study of Intravenous Gene Transfer With an AAV9 Vector Expressing Human Beta-galactosidase in Type I and Type II GM1 Gangliosidosis (PHASE1, PHASE2)
• Physical Activity and Insulin Sensitivity Dynamics (NA)
• Sore Throat After Open Neck Elective Surgery (PHASE4)
• Evaluation of Low Level Laser Therapy and Lidocaine Versus Chlorhexidine for the Management of Traumatic Oral Ulcers in Children (NA)
• Comparison of Low-cost Interventions for Pain Reduction During Radial Artery Puncture in the Emergency Department: A Three-arm Randomized Controlled Trial (NA)
• "Supracondylar Radial Nerve Block Guided by Ultrasound Versus Hematoma Block for Analgesic Management in Closed Reduction of Distal Radius Fractures" (NA)

Primary sources

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