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Chlorhexidine Lavage Solution
Chlorhexidine lavage solution is an antimicrobial rinse that disrupts bacterial cell membranes and denatures proteins to reduce microbial load in surgical or wound irrigation applications.
Chlorhexidine lavage solution is an antimicrobial rinse that disrupts bacterial cell membranes and denatures proteins to reduce microbial load in surgical or wound irrigation applications. Used for Surgical site irrigation and infection prevention, Wound lavage and decontamination.
At a glance
| Generic name | Chlorhexidine Lavage Solution |
|---|---|
| Sponsor | Hamilton Health Sciences Corporation |
| Drug class | Antimicrobial/Antiseptic agent |
| Target | Bacterial cell membrane and proteins |
| Modality | Small molecule |
| Therapeutic area | Infection Prevention / Surgery |
| Phase | Phase 3 |
Mechanism of action
Chlorhexidine is a broad-spectrum antimicrobial agent that works by disrupting bacterial cell membranes and precipitating cellular proteins, leading to cell death. When used as a lavage solution, it provides local antimicrobial activity to reduce infection risk in surgical sites or contaminated wounds. The solution format allows for direct irrigation and contact with affected tissues.
Approved indications
- Surgical site irrigation and infection prevention
- Wound lavage and decontamination
Common side effects
- Local irritation or burning at application site
- Allergic contact dermatitis
- Tissue toxicity with prolonged exposure
Key clinical trials
- Effect of Antiseptic Irrigations With 0.05% Chlorhexidine Gluconate (Irrisept) Versus Normal Saline on Fasciocutaneous Flap-Based Closure of Pilonidal Disease (NA)
- Non-Surgical Treatment of Periodontitis With Adjunctive Sodium Hypochlorite/Amino Acids and Cross-Linked Hyaluronic Acid (NA)
- CLinical Evaluation of ANtiseptic Skin Preparation in Revision Total Joint Arthroplasty of the Hip and Knee (NA)
- Comparing Two Root Canal Cleaning Solutions (Chlorhexidine vs. Sodium Hypochlorite) for Pain After Treatment (NA)
- Influence of Antiseptic Washes on Wound Healing Complications After THA (NA)
- Irrisept vs Traditional Antibiotic Irrigation for Virgin Penile Prosthesis Placement (PHASE3)
- Clinical and Radiographic Success Rate of Pulpotomy Versus Pulpectomy for Management of Primary Teeth With Deep Caries (PHASE2)
- Chlorhexidine Antiseptic Irrigation of the Bowel Segment During Radical Cystectomy and Urinary Diversion (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |