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Chlorhexidine - Isopropyl alcohol
Chlorhexidine-isopropyl alcohol is a topical antiseptic combination that kills microorganisms through dual antimicrobial action.
Chlorhexidine-isopropyl alcohol is a topical antiseptic combination that kills microorganisms through dual antimicrobial action. Used for Skin antisepsis and disinfection prior to medical procedures, Wound cleansing and antisepsis.
At a glance
| Generic name | Chlorhexidine - Isopropyl alcohol |
|---|---|
| Also known as | Chlora-Prep |
| Sponsor | Case Western Reserve University |
| Drug class | Topical antiseptic combination |
| Modality | Small molecule |
| Therapeutic area | Infection Prevention / Dermatology |
| Phase | FDA-approved |
Mechanism of action
Chlorhexidine is a broad-spectrum antimicrobial agent that disrupts bacterial cell membranes and denatures proteins, while isopropyl alcohol provides rapid antimicrobial activity through protein denaturation and cell membrane disruption. The combination provides both rapid kill (alcohol) and sustained antimicrobial effect (chlorhexidine), making it effective for skin antisepsis and disinfection.
Approved indications
- Skin antisepsis and disinfection prior to medical procedures
- Wound cleansing and antisepsis
Common side effects
- Skin irritation
- Contact dermatitis
- Allergic reaction
Key clinical trials
- CLinical Evaluation of ANtiseptic Skin Preparation in Revision Total Joint Arthroplasty of the Hip and Knee (NA)
- Trigger Point Injections Versus Lidocaine Patch for Myofascial Pain in the Emergency Department (PHASE4)
- Aqueous vs Alcohol Chlorhexidine Skin Preparation for Prevention of Cesarean Section Wound Infections (PHASE4)
- Topical Antimicrobial Effectiveness Testing (PHASE4)
- Topical Antimicrobial Effectiveness Testing (PHASE4)
- Test for Pre Operative Skin Preparations (PHASE3)
- Pilot Evaluation of the Application Procedure on the Antimicrobial Effects of 2 Antiseptics (PHASE3)
- Preoperative Skin Preparation Evaluation (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Chlorhexidine - Isopropyl alcohol CI brief — competitive landscape report
- Chlorhexidine - Isopropyl alcohol updates RSS · CI watch RSS
- Case Western Reserve University portfolio CI