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Chlorhexidine gluconate (4%)

The Cooper Health System · FDA-approved active Small molecule Under review

Chlorhexidine gluconate (4%) is a Antimicrobial agent / Antiseptic Small molecule drug developed by The Cooper Health System. It is currently FDA-approved for Oral antisepsis and plaque reduction, Skin antisepsis and wound irrigation, Preoperative skin preparation. Also known as: Hibiclens, CHG 4% solution, topical antiseptic.

Chlorhexidine gluconate is a broad-spectrum antimicrobial agent that disrupts bacterial cell membranes and denatures proteins, leading to rapid bactericidal and bacteriostatic effects.

Chlorhexidine gluconate (4%) is used in medical settings for various purposes, including pain management through interventions such as Epidural and TAP Block. It has also been studied for its potential use in conditions such as COPD, CHF, and Dialysis, as well as in homecare visits for high-risk adults.

At a glance

Generic nameChlorhexidine gluconate (4%)
Also known asHibiclens, CHG 4% solution, topical antiseptic
SponsorThe Cooper Health System
Drug classAntimicrobial agent / Antiseptic
ModalitySmall molecule
Therapeutic areaInfectious Disease / Antisepsis
PhaseFDA-approved

Mechanism of action

Chlorhexidine is a cationic biguanide that binds to negatively charged bacterial cell membranes, causing leakage of cellular contents and protein denaturation. It is effective against a wide range of gram-positive and gram-negative bacteria, as well as some fungi and viruses. The 4% formulation is commonly used for topical antisepsis and oral rinse applications.

Approved indications

Common side effects

Key clinical trials

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results

Competitive intelligence

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Frequently asked questions about Chlorhexidine gluconate (4%)

What is Chlorhexidine gluconate (4%)?

Chlorhexidine gluconate (4%) is a Antimicrobial agent / Antiseptic drug developed by The Cooper Health System, indicated for Oral antisepsis and plaque reduction, Skin antisepsis and wound irrigation, Preoperative skin preparation.

How does Chlorhexidine gluconate (4%) work?

Chlorhexidine gluconate is a broad-spectrum antimicrobial agent that disrupts bacterial cell membranes and denatures proteins, leading to rapid bactericidal and bacteriostatic effects.

What is Chlorhexidine gluconate (4%) used for?

Chlorhexidine gluconate (4%) is indicated for Oral antisepsis and plaque reduction, Skin antisepsis and wound irrigation, Preoperative skin preparation, Oral rinse for gingivitis and periodontal disease prevention.

Who makes Chlorhexidine gluconate (4%)?

Chlorhexidine gluconate (4%) is developed and marketed by The Cooper Health System (see full The Cooper Health System pipeline at /company/the-cooper-health-system).

Is Chlorhexidine gluconate (4%) also known as anything else?

Chlorhexidine gluconate (4%) is also known as Hibiclens, CHG 4% solution, topical antiseptic.

What drug class is Chlorhexidine gluconate (4%) in?

Chlorhexidine gluconate (4%) belongs to the Antimicrobial agent / Antiseptic class. See all Antimicrobial agent / Antiseptic drugs at /class/antimicrobial-agent-antiseptic.

What development phase is Chlorhexidine gluconate (4%) in?

Chlorhexidine gluconate (4%) is FDA-approved (marketed).

What are the side effects of Chlorhexidine gluconate (4%)?

Common side effects of Chlorhexidine gluconate (4%) include Tooth staining (brown discoloration), Taste alteration, Oral irritation or soreness, Allergic contact dermatitis (topical use), Calculus buildup.

Related

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing