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Chlorhexidine digluconate, povidone iodine
This combination of chlorhexidine digluconate and povidone iodine works as a broad-spectrum antimicrobial agent that disrupts bacterial cell membranes and denatures proteins.
This combination of chlorhexidine digluconate and povidone iodine works as a broad-spectrum antimicrobial agent that disrupts bacterial cell membranes and denatures proteins. Used for Skin antisepsis and disinfection, Wound irrigation and cleansing, Oral rinse for antimicrobial purposes.
At a glance
| Generic name | Chlorhexidine digluconate, povidone iodine |
|---|---|
| Sponsor | King Abdulaziz University |
| Drug class | Topical antimicrobial antiseptic |
| Modality | Small molecule |
| Therapeutic area | Infection Prevention / Antisepsis |
| Phase | FDA-approved |
Mechanism of action
Chlorhexidine digluconate is a cationic biguanide that disrupts bacterial cell membranes and precipitates cytoplasmic contents, while povidone iodine releases iodine which oxidizes and denatures microbial proteins and nucleic acids. Together, they provide synergistic antimicrobial activity against a wide range of gram-positive and gram-negative bacteria, fungi, and some viruses.
Approved indications
- Skin antisepsis and disinfection
- Wound irrigation and cleansing
- Oral rinse for antimicrobial purposes
Common side effects
- Local irritation or burning
- Allergic contact dermatitis
- Iodine sensitivity reactions
Key clinical trials
- Surgical Site Preparation in Subjects Undergoing Medical Thoracoscopy (NA)
- CLinical Evaluation of ANtiseptic Skin Preparation in Revision Total Joint Arthroplasty of the Hip and Knee (NA)
- Effectiveness of Chlorhexidine Impregnated Gauze Versus Povidone Iodine Dressing in Post Trauma Wound Care (NA)
- Evaluation of Percutaneous Cryoneurotomy Compared to Surgical Open Neurotomy for the Management of Equinovarus Foot Deformity in Patients With Refractory Lower Limb Spasticity After Stroke (NA)
- Influence of Antiseptic Washes on Wound Healing Complications After THA (NA)
- Effectiveness of Screening and Decolonization of S. Aureus to Prevent S. Aureus Surgical Site Infections in Surgery Outpatients
- Pilot Evaluation of the Application Procedure on the Antimicrobial Effects of 2 Antiseptics (PHASE3)
- EFFECT OF PERIODONTAL TREATMENT ON ALZHEIMER DISEASE-ASSOCIATED OUTCOMES (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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