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chlorhexidine digluconate
Chlorhexidine digluconate is a broad-spectrum antimicrobial agent that disrupts bacterial cell membranes and denatures proteins, leading to rapid bactericidal and bacteriostatic effects.
Chlorhexidine digluconate is a broad-spectrum antimicrobial agent that disrupts bacterial cell membranes and denatures proteins, leading to rapid bactericidal and bacteriostatic effects. Used for Oral antiseptic and antimicrobial rinse for plaque and gingivitis prevention, Topical antiseptic for wound irrigation and skin disinfection, Oral care in hospitalized and immunocompromised patients.
At a glance
| Generic name | chlorhexidine digluconate |
|---|---|
| Also known as | Periogard oral rinse |
| Sponsor | Universidade Federal do Ceara |
| Drug class | Antimicrobial agent / Antiseptic |
| Target | Bacterial cell membrane and proteins |
| Modality | Small molecule |
| Therapeutic area | Infectious Disease / Oral Care |
| Phase | FDA-approved |
Mechanism of action
Chlorhexidine digluconate is a cationic biguanide that binds to negatively charged bacterial cell membranes, causing leakage of cellular contents and protein denaturation. It is effective against a wide range of gram-positive and gram-negative bacteria, as well as some fungi and viruses. The digluconate salt formulation enhances solubility and stability for topical and oral rinse applications.
Approved indications
- Oral antiseptic and antimicrobial rinse for plaque and gingivitis prevention
- Topical antiseptic for wound irrigation and skin disinfection
- Oral care in hospitalized and immunocompromised patients
Common side effects
- Tooth staining (brown discoloration)
- Taste alteration
- Oral irritation or ulceration
- Allergic contact dermatitis (topical use)
Key clinical trials
- Immediate Restoration of a New Implant With High Primary Stability (NA)
- Effect of Antiseptic Irrigations With 0.05% Chlorhexidine Gluconate (Irrisept) Versus Normal Saline on Fasciocutaneous Flap-Based Closure of Pilonidal Disease (NA)
- Hyaluronic Gel vs Chlorhexidine in Periodontal Patients (NA)
- The Aim of This Study is to Compare the Effects of Two Different Topical Agents (KLOROBEN® and KLORHEX PLUS®) Used in the Surgical Extraction of Mandibular Bilateral Mesioangular Impacted Third Molars on Postoperative Pain, Edema, and Trismus. (NA)
- PMPR and Chlorhexidine on Periodontal Disease and Vascular Function (NA)
- Antiplaque Efficacy and Patient Reported Outcome of Chlorohexidine, Cetylpyridinium Chloride, and Essential Oil Mouthwashes in Orthodontic Patients (NA)
- Microbiological Effect of 0.12% Chlorhexidine Digluconate and 0.05% Cetylpyridinium Chloride vs Probiotics (Lactobacillus Reuteri Prodentis) on Porphyromonas Gingivalis. (PHASE4)
- To Compare Post-Extraction Use of a Novel Ethylenediaminetetraacetic Acid (EDTA) Post-operative Mouth Rinse and Daily Use EDTA Mouth Rinse and Standard 0.12% Chlorhexidine (CHX) Post-operative Mouth Rinse and Daily Use Essential Oil (EO) Mouth Rinse. (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |