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Chlorhexidine 0.2%
Chlorhexidine is a broad-spectrum antimicrobial agent that disrupts bacterial cell membranes and denatures proteins, leading to rapid bactericidal and bacteriostatic effects.
Chlorhexidine is a broad-spectrum antimicrobial agent that disrupts bacterial cell membranes and denatures proteins, leading to rapid bactericidal and bacteriostatic effects. Used for Oral antisepsis and plaque reduction (Phase 3 context suggests oral rinse formulation), Antimicrobial prophylaxis in oral or dental procedures.
At a glance
| Generic name | Chlorhexidine 0.2% |
|---|---|
| Also known as | Chlorhexidine, Control group |
| Sponsor | University of Milan |
| Drug class | Antimicrobial agent / Antiseptic |
| Modality | Small molecule |
| Therapeutic area | Infectious Disease / Oral Health |
| Phase | Phase 3 |
Mechanism of action
Chlorhexidine is a cationic biguanide that binds to negatively charged bacterial cell membranes, causing leakage of cellular contents and protein denaturation. It is effective against a wide range of gram-positive and gram-negative bacteria, as well as some fungi and viruses. The 0.2% formulation is commonly used as an oral rinse or topical antiseptic.
Approved indications
- Oral antisepsis and plaque reduction (Phase 3 context suggests oral rinse formulation)
- Antimicrobial prophylaxis in oral or dental procedures
Common side effects
- Tooth staining (brown discoloration)
- Taste alteration
- Oral irritation or ulceration
- Calculus buildup
Key clinical trials
- Immediate Restoration of a New Implant With High Primary Stability (NA)
- PMPR and Chlorhexidine on Periodontal Disease and Vascular Function (NA)
- To Compare Post-Extraction Use of a Novel Ethylenediaminetetraacetic Acid (EDTA) Post-operative Mouth Rinse and Daily Use EDTA Mouth Rinse and Standard 0.12% Chlorhexidine (CHX) Post-operative Mouth Rinse and Daily Use Essential Oil (EO) Mouth Rinse. (NA)
- Antimicrobial Effect of Tropolone Containing Versus Tropolone Free Mouthwash (EARLY_PHASE1)
- Effectiveness of Chlorhexidine Impregnated Gauze Versus Povidone Iodine Dressing in Post Trauma Wound Care (NA)
- Assessment of Topical Application of Chitosan 0.2% Chlorhexidine Gel on Wound Healing in Diabetic Patients (NA)
- Comparative Evaluation of Guava Leaf Extract and Chlorhexidine Mouthwash in Patients With Chronic Gingivitis (NA)
- The Efficacy of Adjuvant Oral Care in Prevention of Ventilator Associated Pneumonia. (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |