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SOMATROGON
SOMATROGON is a drug. It is currently FDA-approved (first approved 2022) for Growth failure due to inadequate growth hormone secretion.
Somatrogon is a marketed drug indicated for growth failure due to inadequate growth hormone secretion, positioning it in a niche but critical therapeutic area. Its key strength lies in its mechanism of action, which addresses the underlying deficiency directly, potentially offering a more targeted treatment option compared to broader alternatives. The primary risk to consider is the key composition patent expiry in 2028, which could lead to increased competition from generics and biosimilars.
At a glance
| Generic name | SOMATROGON |
|---|---|
| Modality | Recombinant protein |
| Phase | FDA-approved |
| First approval | 2022 |
Approved indications
- Growth failure due to inadequate growth hormone secretion
Common side effects
- Injection site reactions
- Nasopharyngitis
- Headache
- Pyrexia
- Anemia
- Cough
- Vomiting
- Hypothyroidism
- Abdominal pain
- Rash
- Oropharyngeal pain
Drug interactions
- Replacement Glucocorticoid Treatment (e.g., Cortisone Acetate, Prednisone)
- Supraphysiologic Glucocorticoid Treatment
- Cytochrome P450-Metabolized Drugs
- Oral Estrogen
- Insulin and/or Other Antihyperglycemic Agents
Key clinical trials
- Comparison of Weekly Somatrogon to Daily Genotropin in Children Born Small for Gestational Age or With Idiopathic Short Stature. (PHASE3)
- Evaluation of (Cardio)Metabolic and Auxological Outcomes of GHD Patients Under rhGH or LAGH With Stratification According to IGF-1 Levels (NA)
- Korean Post-marketing Surveillance Ngenla® Pre-filled Pen Injection for the Treatment of Pediatric Patients With Growth Disturbance Due to Insufficient Secretion of Growth Hormone
- A Study to Learn About Somatrogon in Patients With Pediatric Growth Hormone Deficiency (p GHD) in India.
- Ngenla Subcutaneous Injection Special Investigation
- Safety and Efficacy Phase 3 Study of Long-acting hGH (MOD-4023) in Growth Hormone Deficient Children (PHASE3)
- Patient Perception of Treatment Burden in Weekly Versus Daily Growth Hormone Injections in Children With GHD (PHASE3)
- Safety and Efficacy Study of MOD-4023 to Treat Children With Growth Hormone Deficiency (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| FDA label | Mechanism, indications, dosing, boxed warnings, drug interactions |
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- SOMATROGON CI brief — competitive landscape report
- SOMATROGON updates RSS · CI watch RSS
Frequently asked questions about SOMATROGON
What is SOMATROGON?
What is SOMATROGON used for?
When was SOMATROGON approved?
What development phase is SOMATROGON in?
What are the side effects of SOMATROGON?
Related
- Indication: Drugs for Growth failure due to inadequate growth hormone secretion
- Compare: SOMATROGON vs similar drugs
- Pricing: SOMATROGON cost, discount & access