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Cetuximab, Oxaliplatin, Leucovorin, 5FU, Irinotecan
Cetuximab, Oxaliplatin, Leucovorin, 5FU, Irinotecan is a Antineoplastic agents Small molecule drug developed by Central European Cooperative Oncology Group. It is currently in Phase 2 development for Colorectal cancer, Head and neck cancer.
Inhibits epidermal growth factor receptor (EGFR) and vascular endothelial growth factor receptor (VEGFR) tyrosine kinases.
Inhibits epidermal growth factor receptor (EGFR) and vascular endothelial growth factor receptor (VEGFR) tyrosine kinases. Used for Colorectal cancer, Head and neck cancer.
At a glance
| Generic name | Cetuximab, Oxaliplatin, Leucovorin, 5FU, Irinotecan |
|---|---|
| Sponsor | Central European Cooperative Oncology Group |
| Drug class | Antineoplastic agents |
| Target | EGFR, VEGFR |
| Modality | Small molecule |
| Therapeutic area | Oncology |
| Phase | Phase 2 |
Mechanism of action
Cetuximab is a monoclonal antibody that binds to the epidermal growth factor receptor (EGFR) and inhibits its tyrosine kinase activity, thereby inhibiting tumor growth and angiogenesis. Oxaliplatin is a platinum-based chemotherapy drug that works by cross-linking DNA, thereby inhibiting DNA replication and transcription. Leucovorin is a folate analog that inhibits the metabolism of 5-fluorouracil (5-FU) and irinotecan, allowing them to exert their cytotoxic effects on cancer cells. 5-FU is a thymidylate synthase inhibitor that works by inhibiting the synthesis of thymidine, a nucleotide required for DNA replication. Irinotecan is a topoisomerase I inhibitor that works by inhibiting the enzyme topoisomerase I, which is involved in DNA replication and transcription.
Approved indications
- Colorectal cancer
- Head and neck cancer
Common side effects
- Diarrhea
- Fatigue
- Nausea
Key clinical trials
- Testing Pump Chemotherapy in Addition to Standard of Care Chemotherapy Versus Standard of Care Chemotherapy Alone for Patients With Unresectable Colorectal Liver Metastases: The PUMP Trial (PHASE3)
- A Study of Amivantamab and mFOLFOX6 or FOLFIRI Versus Cetuximab and mFOLFOX6 or FOLFIRI as First-line Treatment in Participants With KRAS/NRAS and BRAF Wild-type Unresectable or Metastatic Left-sided Colorectal Cancer (PHASE3)
- A Phase II Study of AMT-676 Combination Therapies in Advanced Colorectal Cancer (PHASE2)
- A Study of the Pan-KRAS Inhibitor LY4066434 in Participants With KRAS Mutant Solid Tumors (PHASE1)
- Study of Pembrolizumab (MK-3475) Versus Chemotherapy in Chinese Participants With Stage IV Colorectal Cancer (MK-3475-C66) (PHASE3)
- A Study Evaluating the Safety and Efficacy of Targeted Therapies in Subpopulations of Patients With Metastatic Colorectal Cancer (INTRINSIC) (PHASE1)
- A Study of ASP3082 in Adults With Advanced Solid Tumors (PHASE1)
- Clinical Study on the First-line Treatment of Advanced Colorectal Cancer With Simultaneous Infusion of Levozolinate for Injection and 5-FU (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Cetuximab, Oxaliplatin, Leucovorin, 5FU, Irinotecan CI brief — competitive landscape report
- Cetuximab, Oxaliplatin, Leucovorin, 5FU, Irinotecan updates RSS · CI watch RSS
- Central European Cooperative Oncology Group portfolio CI
Frequently asked questions about Cetuximab, Oxaliplatin, Leucovorin, 5FU, Irinotecan
What is Cetuximab, Oxaliplatin, Leucovorin, 5FU, Irinotecan?
How does Cetuximab, Oxaliplatin, Leucovorin, 5FU, Irinotecan work?
What is Cetuximab, Oxaliplatin, Leucovorin, 5FU, Irinotecan used for?
Who makes Cetuximab, Oxaliplatin, Leucovorin, 5FU, Irinotecan?
What drug class is Cetuximab, Oxaliplatin, Leucovorin, 5FU, Irinotecan in?
What development phase is Cetuximab, Oxaliplatin, Leucovorin, 5FU, Irinotecan in?
What are the side effects of Cetuximab, Oxaliplatin, Leucovorin, 5FU, Irinotecan?
What does Cetuximab, Oxaliplatin, Leucovorin, 5FU, Irinotecan target?
Related
- Drug class: All Antineoplastic agents drugs
- Target: All drugs targeting EGFR, VEGFR
- Manufacturer: Central European Cooperative Oncology Group — full pipeline
- Therapeutic area: All drugs in Oncology
- Indication: Drugs for Colorectal cancer
- Indication: Drugs for Head and neck cancer
- Compare: Cetuximab, Oxaliplatin, Leucovorin, 5FU, Irinotecan vs similar drugs
- Pricing: Cetuximab, Oxaliplatin, Leucovorin, 5FU, Irinotecan cost, discount & access