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Celestone + Celestone
Betamethasone is a corticosteroid that suppresses the immune system and reduces inflammation by binding to glucocorticoid receptors.
Betamethasone is a corticosteroid that suppresses the immune system and reduces inflammation by binding to glucocorticoid receptors. Used for Inflammatory and autoimmune disorders (rheumatoid arthritis, lupus, vasculitis), Allergic reactions and dermatological conditions, Respiratory conditions (asthma, COPD exacerbations).
At a glance
| Generic name | Celestone + Celestone |
|---|---|
| Sponsor | McMaster University |
| Drug class | Corticosteroid (glucocorticoid) |
| Target | Glucocorticoid receptor (GR) |
| Modality | Small molecule |
| Therapeutic area | Immunology / Rheumatology / Endocrinology |
| Phase | FDA-approved |
Mechanism of action
Betamethasone acts as a synthetic glucocorticoid that binds to intracellular glucocorticoid receptors, translocating to the nucleus to modulate gene expression. This results in decreased production of pro-inflammatory cytokines, reduced immune cell activation and migration, and suppression of inflammatory mediators. The dual formulation (Celestone + Celestone) likely represents a combination of immediate-release and depot formulations for extended therapeutic coverage.
Approved indications
- Inflammatory and autoimmune disorders (rheumatoid arthritis, lupus, vasculitis)
- Allergic reactions and dermatological conditions
- Respiratory conditions (asthma, COPD exacerbations)
- Adrenal insufficiency
Common side effects
- Hyperglycemia
- Hypertension
- Osteoporosis
- Immunosuppression / increased infection risk
- Insomnia
- Mood changes
- Adrenal suppression
Key clinical trials
- Comparative Bioavailability Study Between Etoricoxib / Betamethasone Administered Individually or in Combination (PHASE1)
- Evaluation the Topical Apremilast Nanoformulation in Treatment of Localized Plaque Psoriasis (NA)
- Assessing Psoriasis Treatment Outcomes (NA)
- A Phase III Trial To Evaluate The Efficacy And Safety Of MC2-01 Cream Compared To CAL/BDP Gel and Vehicle In Plaque Psoriasis Subjects (PHASE3)
- Comparing Different Doses of Corticosteroids in Local Infiltration Analgesia (LIA) for Total Knee Arthroplasty (NA)
- Ropiclobet for Regional Anesthesia and Post-Operative Pain Control in Upper Extremity Surgery (PHASE2)
- Single Dose of Antenatal Corticosteroids for Pregnancies at Risk of Preterm Delivery (SNACS) (PHASE4)
- Betamethasone and Complications of Lower Third Molar Surgery (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |