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Ceftriaxone v penicillin and gentamicin

Kamuzu University of Health Sciences · FDA-approved active Small molecule Quality 58/100

Ceftriaxone v penicillin and gentamicin is a Third-generation cephalosporin Small molecule drug developed by Kamuzu University of Health Sciences. It is currently FDA-approved.

Ceftriaxone inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs).

Ceftriaxone is a third-generation cephalosporin antibiotic used to treat a wide range of bacterial infections. It is often compared to penicillin and gentamicin due to its broad-spectrum activity and favorable pharmacokinetic properties. Unlike penicillin, ceftriaxone has a longer half-life and can be administered less frequently. Compared to gentamicin, ceftriaxone has a lower risk of nephrotoxicity and ototoxicity. However, it is important to note that ceftriaxone should not be used in patients with a history of severe allergic reactions to cephalosporins or penicillins.

At a glance

Generic name	Ceftriaxone v penicillin and gentamicin
Sponsor	Kamuzu University of Health Sciences
Drug class	Third-generation cephalosporin
Target	Penicillin-binding proteins (PBPs)
Modality	Small molecule
Therapeutic area	Metabolic
Phase	FDA-approved

Mechanism of action

Ceftriaxone works by interfering with the synthesis of the bacterial cell wall, leading to cell lysis and death.

Approved indications

Boxed warnings

Hypersensitivity reactions, including anaphylaxis, may occur.

Common side effects

Diarrhea
Nausea
Rash
Vomiting
Injection site pain

Drug interactions

Warfarin: Increased risk of bleeding
Probenecid: Increased serum levels of ceftriaxone
Aminoglycosides: Increased risk of nephrotoxicity

Key clinical trials

Patients Response to Early Switch To Oral:Osteomyelitis Study (EARLY_PHASE1)
Infant Severe Sepsis and Bacterial Meningitis in Malawi (PHASE4)

Patents

Patent	Expiry	Type
US4326009A

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

Source	Used for
ClinicalTrials.gov	Trial enrolment, design, endpoints, results
FDA Orange Book	Patents + exclusivity

Competitive intelligence

For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:

Ceftriaxone v penicillin and gentamicin CI brief — competitive landscape report
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Kamuzu University of Health Sciences portfolio CI

Frequently asked questions about Ceftriaxone v penicillin and gentamicin

What is Ceftriaxone v penicillin and gentamicin?

Ceftriaxone v penicillin and gentamicin is a Third-generation cephalosporin drug developed by Kamuzu University of Health Sciences.

How does Ceftriaxone v penicillin and gentamicin work?

Ceftriaxone inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs).

Who makes Ceftriaxone v penicillin and gentamicin?

Ceftriaxone v penicillin and gentamicin is developed and marketed by Kamuzu University of Health Sciences (see full Kamuzu University of Health Sciences pipeline at /company/kamuzu-university-of-health-sciences).

What drug class is Ceftriaxone v penicillin and gentamicin in?

Ceftriaxone v penicillin and gentamicin belongs to the Third-generation cephalosporin class. See all Third-generation cephalosporin drugs at /class/third-generation-cephalosporin.

What development phase is Ceftriaxone v penicillin and gentamicin in?

Ceftriaxone v penicillin and gentamicin is FDA-approved (marketed).

What are the side effects of Ceftriaxone v penicillin and gentamicin?

Common side effects of Ceftriaxone v penicillin and gentamicin include Diarrhea, Nausea, Rash, Vomiting, Injection site pain.

What does Ceftriaxone v penicillin and gentamicin target?

Ceftriaxone v penicillin and gentamicin targets Penicillin-binding proteins (PBPs) and is a Third-generation cephalosporin.

Drug class: All Third-generation cephalosporin drugs
Target: All drugs targeting Penicillin-binding proteins (PBPs)
Manufacturer: Kamuzu University of Health Sciences — full pipeline
Therapeutic area: All drugs in Metabolic
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