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Rocephin (ceftriaxone)
Ceftriaxone (Rocephin) is the most prescribed parenteral antibiotic worldwide, developed by Roche and approved in 1984. First-line for meningitis and gonorrhea. Available generically. WHO Essential Medicine.
At a glance
| Generic name | ceftriaxone |
|---|---|
| Also known as | Rocephin |
| Sponsor | Generic (originally Roche) |
| Drug class | Cephalosporin antibiotic (third-generation) |
| Target | Alpha-synuclein, D-amino-acid oxidase, Penicillin-binding protein 1A |
| Modality | Small molecule |
| Therapeutic area | Immunology |
| Phase | FDA-approved |
| First approval | 1984-12-21 (United States) |
Approved indications
- Acute gonococcal cervicitis
- Acute gonococcal endometritis
- Acute gonococcal urethritis
- Adult Gonococcal Conjunctivitis
- Bacterial arthritis
- Bacterial infection due to Klebsiella pneumoniae
- Bacterial infection due to Serratia
- Bacterial meningitis
- Bacterial pneumonia
- Bacterial septicemia
- Bacterial urinary infection
- Chancroid
- Disseminated Gonococcal Infection
- E. Coli Joint Infection
- E. Coli Osteomyelitis
- E. Coli Peritonitis
- E. Coli Septic Arthritis
- Endometritis
- Enterobacter Osteomyelitis
- Enterobacter Pneumonia
Common side effects
- ALT elevation
- AST elevation
- Eosinophilia
- Thrombocytosis
- Diarrhea/loose stools
- Leukopenia
- Rash
- Pain, induration and tenderness
- BUN elevation
- Granulocytopenia
- Injection site pain
- Blood creatinine increased
Serious adverse events
- Anaphylaxis/anaphylactoid reactions
- Stevens-Johnson syndrome
- Toxic epidermal necrolysis (Lyell's syndrome)
- Erythema multiforme
- Seizures
- Encephalopathy
- Acute renal failure
- Agranulocytosis
- Bronchospasm
- Kernicterus
Key clinical trials
- Therapeutic Monitoring of Ceftriaxone, Prescribed at High Doses, in the Treatment of Meningitis and Others Neurological Infections. (Phase 4)
- Overall Patient Care in a Montpelier Sexual Health Center (CeGIDD). Response Rate to Ceftriaxone 1g IM in Gonorrhoea : a French Retrospective Monocentric Study (N/A)
- Antibiotic Prophylaxis in Critically Ill Patients After Suspected Aspiration (Phase 4)
- The EDGE Consortium: A Randomized Trial of Preoperative Prophylactic Antibiotics Prior to Percutaneous Nephrolithotomy: Part 1 (Phase 4)
- The Influence of Antibiotics on the Incidence of Biliary Tract Infections After PTCD for Malignant Obstructive Jaundice (N/A)
- Efficacy of Proton Pump Inhibitors in Cirrhotic Patients With Acute Variceal Bleeding (Phase 4)
- COMPARISON OF CLINICAL EFFICACY OF COMBINATION Amoxycillin Plus Clavulanic Acid and Oxacillin Plus Ceftriaxone for HOSPITAL TREATMENT OF COMMUNITY Acquired PNEUMONIA IN CHILDREN : A Randomized Clinica (Phase 4)
- Effect Of Early Versus Delayed Laparoscopic Cholecystectomy On Postoperative Mortality, Morbidity and Difficult Cholecystectomy In Patients With Grade II Cholecystitis According To Tokyo 2018 Guidelin (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| FDA label | Mechanism, indications, dosing, boxed warnings, drug interactions |
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |