Last reviewed 2026-04-22 · How we verify

CDP-Choline

CDP-Choline is a precursor to phosphatidylcholine that increases acetylcholine synthesis and enhances cell membrane integrity in the brain.

CDP-Choline is a precursor to phosphatidylcholine that increases acetylcholine synthesis and enhances cell membrane integrity in the brain. Used for Cognitive decline and memory impairment, Stroke recovery and neuroprotection, Age-related cognitive disorders.

At a glance

Mechanism of action

CDP-Choline (cytidine diphosphate choline) is converted to phosphatidylcholine, a major component of neuronal cell membranes. It increases acetylcholine production and promotes membrane phospholipid synthesis, thereby supporting neuronal function and protecting against neurodegeneration. This mechanism supports cognitive function and neuroprotection in conditions affecting the central nervous system.

Approved indications

• Cognitive decline and memory impairment
• Stroke recovery and neuroprotection
• Age-related cognitive disorders

Common side effects

• Headache
• Insomnia
• Gastrointestinal upset
• Dizziness

Key clinical trials

• Improving Sleep and AD Biomarkers (NA)
• Combination of Conditioned Medium and Umbilical Cord-Mesenchymal Stem Cells Therapy for Acute Stroke Infarct (PHASE1, PHASE2)
• Evaluation of BRUDYGLAUCO (DHA + Citicoline) in Patients With Glaucoma (NA)
• A Brain-Computer Interface-Based Attention Training Program Compared With Methylphenidate and Citicoline
• Evaluation of the Impact of a Nutritional Formulation on Cognitive Performance Following Stress Exposure. (NA)
• Vision Preservation and Restoration Following a 6 Month Trial of GlaucoCetin (NA)
• Improving Sleep and Cognition in Alzheimer's Disease (NA)
• Citicoline in Youth Alcohol Use Disorder (PHASE2)

Primary sources

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