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Carvedilol IR 25mg, BID
Carvedilol is a non-selective beta-adrenergic receptor antagonist with alpha-1 blocking activity that reduces heart rate, blood pressure, and cardiac workload.
Carvedilol is a non-selective beta-adrenergic receptor antagonist with alpha-1 blocking activity that reduces heart rate, blood pressure, and cardiac workload. Used for Heart failure with reduced ejection fraction, Hypertension, Angina pectoris.
At a glance
| Generic name | Carvedilol IR 25mg, BID |
|---|---|
| Also known as | Dilatrend IR |
| Sponsor | Chong Kun Dang Pharmaceutical |
| Drug class | Beta-blocker with alpha-1 antagonist activity |
| Target | Beta-1 adrenergic receptor, Beta-2 adrenergic receptor, Alpha-1 adrenergic receptor |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | Phase 3 |
Mechanism of action
Carvedilol blocks beta-1, beta-2, and alpha-1 adrenergic receptors, reducing sympathetic nervous system activity on the heart and blood vessels. This dual action decreases heart rate and contractility while causing vasodilation, leading to reduced blood pressure and improved cardiac efficiency. It is commonly used in heart failure and hypertension management.
Approved indications
- Heart failure with reduced ejection fraction
- Hypertension
- Angina pectoris
- Post-myocardial infarction
Common side effects
- Dizziness
- Fatigue
- Hypotension
- Bradycardia
- Hyperglycemia
- Erectile dysfunction
Key clinical trials
- Immediate Release Versus Slow Release Carvedilol in Heart Failure (PHASE4)
- Efficacy and Safety of Carvedilol SR Versus Carvedilol IR in Patients With Essential Hypertension (PHASE3)
Primary sources
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| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |