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Candesartan cilexetil / hydrochlorothiazide
Candesartan cilexetil / hydrochlorothiazide is a Angiotensin II receptor antagonist / thiazide diuretic combination Small molecule drug developed by Takeda. It is currently FDA-approved for Hypertension, Reduction of cardiovascular risk in hypertensive patients. Also known as: ECARD® Combination Tablets LD&HD.
Candesartan cilexetil blocks angiotensin II receptors to lower blood pressure, while hydrochlorothiazide is a thiazide diuretic that reduces fluid volume.
Candesartan cilexetil blocks angiotensin II receptors to lower blood pressure, while hydrochlorothiazide is a thiazide diuretic that reduces fluid volume. Used for Hypertension, Reduction of cardiovascular risk in hypertensive patients.
At a glance
| Generic name | Candesartan cilexetil / hydrochlorothiazide |
|---|---|
| Also known as | ECARD® Combination Tablets LD&HD |
| Sponsor | Takeda |
| Drug class | Angiotensin II receptor antagonist / thiazide diuretic combination |
| Target | AT1 receptor (angiotensin II type 1 receptor); sodium-chloride cotransporter |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | FDA-approved |
Mechanism of action
Candesartan cilexetil is a prodrug that is converted to candesartan, an angiotensin II receptor antagonist (ARB) that selectively blocks AT1 receptors, preventing vasoconstriction and aldosterone secretion. Hydrochlorothiazide is a thiazide diuretic that inhibits sodium reabsorption in the distal convoluted tubule, promoting sodium and water excretion to reduce blood volume. The combination provides complementary antihypertensive effects through different mechanisms.
Approved indications
- Hypertension
- Reduction of cardiovascular risk in hypertensive patients
Common side effects
- Dizziness
- Hyperkalemia
- Hypokalemia
- Headache
- Fatigue
- Cough
- Hyperuricemia
- Hyperglycemia
Key clinical trials
- Candesartan Cilexetil + Chlorthalidone + Amlodipine Versus Exforge HCT®️ for Systemic Arterial Hypertension (PHASE3)
- The Precision Hypertension Care Study (PHASE4)
- ACEI or ARB and COVID-19 Severity and Mortality in US Veterans
- A Clinical Trial to Evaluate the Blood Pressure Lowering Effect of a Candemore Plus Tab Versus Cantabell Tab in Hypertensive Patients Inadequately Controlled by Candesartan Monotherapy (PHASE4)
- Coronavirus (COVID-19) ACEi/ARB Investigation (PHASE4)
- Candesartan Cilexetil / Hydrochlorothiazide Combination Tablets Special Drug Use Surveillance: Long-term Use (12 Months)
- A Relative Bioavailability Study of a Fixed Dose Combination (FDC) Tablets of GSK587323 (PHASE1)
- Efficacy and Safety of Candesartan Associated With Chlorthalidone Versus Losartan Associated With Hydrochlorothiazide (Hyzaar®) in Essential Hypertension Control (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Candesartan cilexetil / hydrochlorothiazide CI brief — competitive landscape report
- Candesartan cilexetil / hydrochlorothiazide updates RSS · CI watch RSS
- Takeda portfolio CI
Frequently asked questions about Candesartan cilexetil / hydrochlorothiazide
What is Candesartan cilexetil / hydrochlorothiazide?
How does Candesartan cilexetil / hydrochlorothiazide work?
What is Candesartan cilexetil / hydrochlorothiazide used for?
Who makes Candesartan cilexetil / hydrochlorothiazide?
Is Candesartan cilexetil / hydrochlorothiazide also known as anything else?
What drug class is Candesartan cilexetil / hydrochlorothiazide in?
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What are the side effects of Candesartan cilexetil / hydrochlorothiazide?
What does Candesartan cilexetil / hydrochlorothiazide target?
Related
- Drug class: All Angiotensin II receptor antagonist / thiazide diuretic combination drugs
- Target: All drugs targeting AT1 receptor (angiotensin II type 1 receptor); sodium-chloride cotransporter
- Manufacturer: Takeda — full pipeline
- Therapeutic area: All drugs in Cardiovascular
- Indication: Drugs for Hypertension
- Indication: Drugs for Reduction of cardiovascular risk in hypertensive patients
- Also known as: ECARD® Combination Tablets LD&HD
- Compare: Candesartan cilexetil / hydrochlorothiazide vs similar drugs
- Pricing: Candesartan cilexetil / hydrochlorothiazide cost, discount & access