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camrelizumab+apatinib+TMZ

Peking University Cancer Hospital & Institute · Phase 3 active Small molecule

camrelizumab+apatinib+TMZ is a PD-1 inhibitor, VEGFR inhibitor, chemotherapy agent Small molecule drug developed by Peking University Cancer Hospital & Institute. It is currently in Phase 3 development for Metastatic non-small cell lung cancer, PD-L1 positive, Glioblastoma.

Camrelizumab is a PD-1 inhibitor, apatinib is a VEGFR inhibitor, and TMZ is a chemotherapy agent that works by crosslinking DNA.

Camrelizumab is a PD-1 inhibitor, apatinib is a VEGFR inhibitor, and TMZ is a chemotherapy agent that works by crosslinking DNA. Used for Metastatic non-small cell lung cancer, PD-L1 positive, Glioblastoma.

At a glance

Generic namecamrelizumab+apatinib+TMZ
SponsorPeking University Cancer Hospital & Institute
Drug classPD-1 inhibitor, VEGFR inhibitor, chemotherapy agent
TargetPD-1, VEGFR
ModalitySmall molecule
Therapeutic areaOncology
PhasePhase 3

Mechanism of action

Camrelizumab binds to PD-1, preventing its interaction with PD-L1 and thus activating T cells to attack cancer cells. Apatinib inhibits VEGFR, which is involved in angiogenesis, a process that tumors use to grow their own blood supply. TMZ works by causing DNA crosslinks, which prevent cancer cells from replicating.

Approved indications

Common side effects

Key clinical trials

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results

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Frequently asked questions about camrelizumab+apatinib+TMZ

What is camrelizumab+apatinib+TMZ?

camrelizumab+apatinib+TMZ is a PD-1 inhibitor, VEGFR inhibitor, chemotherapy agent drug developed by Peking University Cancer Hospital & Institute, indicated for Metastatic non-small cell lung cancer, PD-L1 positive, Glioblastoma.

How does camrelizumab+apatinib+TMZ work?

Camrelizumab is a PD-1 inhibitor, apatinib is a VEGFR inhibitor, and TMZ is a chemotherapy agent that works by crosslinking DNA.

What is camrelizumab+apatinib+TMZ used for?

camrelizumab+apatinib+TMZ is indicated for Metastatic non-small cell lung cancer, PD-L1 positive, Glioblastoma.

Who makes camrelizumab+apatinib+TMZ?

camrelizumab+apatinib+TMZ is developed by Peking University Cancer Hospital & Institute (see full Peking University Cancer Hospital & Institute pipeline at /company/peking-university-cancer-hospital-institute).

What drug class is camrelizumab+apatinib+TMZ in?

camrelizumab+apatinib+TMZ belongs to the PD-1 inhibitor, VEGFR inhibitor, chemotherapy agent class. See all PD-1 inhibitor, VEGFR inhibitor, chemotherapy agent drugs at /class/pd-1-inhibitor-vegfr-inhibitor-chemotherapy-agent.

What development phase is camrelizumab+apatinib+TMZ in?

camrelizumab+apatinib+TMZ is in Phase 3.

What are the side effects of camrelizumab+apatinib+TMZ?

Common side effects of camrelizumab+apatinib+TMZ include Fatigue, Nausea, Diarrhea, Vomiting, Anemia, Neutropenia.

What does camrelizumab+apatinib+TMZ target?

camrelizumab+apatinib+TMZ targets PD-1, VEGFR and is a PD-1 inhibitor, VEGFR inhibitor, chemotherapy agent.

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