Last reviewed · How we verify
Calcium carbonate/vitamin D3
Calcium carbonate provides supplemental calcium to support bone mineralization, while vitamin D3 enhances intestinal calcium absorption and regulates calcium-phosphate homeostasis.
Calcium carbonate provides supplemental calcium to support bone mineralization, while vitamin D3 enhances intestinal calcium absorption and regulates calcium-phosphate homeostasis. Used for Calcium and vitamin D3 deficiency, Osteoporosis prevention and treatment, Hypoparathyroidism.
At a glance
| Generic name | Calcium carbonate/vitamin D3 |
|---|---|
| Sponsor | University of Alberta |
| Drug class | Mineral supplement / Vitamin supplement combination |
| Modality | Small molecule |
| Therapeutic area | Bone health / Musculoskeletal |
| Phase | FDA-approved |
Mechanism of action
Calcium carbonate serves as a source of elemental calcium necessary for bone formation and maintenance. Vitamin D3 (cholecalciferol) is converted to its active metabolite calcitriol in the kidneys, which increases intestinal absorption of dietary calcium and phosphate, and promotes osteoblast differentiation. Together, these agents work synergistically to maintain serum calcium levels and support skeletal health.
Approved indications
- Calcium and vitamin D3 deficiency
- Osteoporosis prevention and treatment
- Hypoparathyroidism
- Nutritional supplementation in patients with inadequate dietary intake
Common side effects
- Constipation
- Nausea
- Hypercalcemia (with excessive intake)
- Kidney stone formation (with chronic high-dose use)
- Abdominal discomfort
Key clinical trials
- Vitamin k, D-chiro Inositol and α-lactalbumin in Bone Homeostasis
- Effect of Anti-osteoporotic Medications on Nonalcoholic Fatty Liver Disease (PHASE4)
- Study of the Impact of Mother-of-pearl Nutritional Supplementation on the Prevention of Post-menopausal Osteoporosis (NA)
- Efect Supplementation Vitamin D in Diabetes Mellitus Type 2 (NA)
- Effect of Oral Vitamin D3 and Calcium Supplementation on Muscle and Bone Health Among Rural Post-menopausal Women (NA)
- The Effect of Aerobic Exercise on Bone Turnover Markers in Postmenopausal Patients (NA)
- Calcium+Calcitriol Versus PTH for the Prevention of Hypocalcemia in Thyroidectomy. Randomized Clinical Trial (NA)
- Non-inferiority of Lower Dose Calcium Supplementation During Pregnancy (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Calcium carbonate/vitamin D3 CI brief — competitive landscape report
- Calcium carbonate/vitamin D3 updates RSS · CI watch RSS
- University of Alberta portfolio CI