Last reviewed 2026-04-20 · How we verify

C.difficile vaccine (c-difficile-vaccine)

At a glance

Approved indications

No approved indications tracked.

Common side effects

• Injection site pain (pain)
• Fatigue
• Headache
• Myalgia (muscle pain)
• Diarrhoea (diarrhea)
• Arthralgia (joint pain)
• Injection site swelling (swelling)
• Injection site erythema (redness)
• Injection site haemorrhage
• Injection site pain
• Upper respiratory tract infection
• Diarrhoea

Key clinical trials

• To Understand the Safety and Effects of a C. Difficile Vaccine With New Adds-Ons That Will Be Given to Healthy Adults (PHASE1, PHASE2)
• Safety and Immunogenicity Study of GSK's Clostridium Difficile Vaccine 2904545A When Administered in Healthy Adults Aged 18-45 Years and 50-70 Years (PHASE1)
• Study of a Candidate Clostridium Difficile Toxoid Vaccine in Subjects at Risk for C. Difficile Infection (PHASE3)
• A Study To Investigate Two 3-dose Schedules Of A Clostridium Difficile Vaccine In Healthy Adults Aged 65 to 85 Years (PHASE2)
• A Study To Investigate A Clostridium Difficile Vaccine In Healthy Adults Aged 50 To 85 Years, Who Will Each Receive 3 Doses Of Vaccine. (PHASE1)
• Study of Different Formulations of a Clostridium Difficile Toxoid Vaccine Given at Three Different Schedules in Adults (PHASE2)
• Study of a Candidate Clostridium Difficile Toxoid Vaccine in Healthy Adult Subjects Aged 40 to 75 Years in Japan (PHASE1, PHASE2)
• Clostridium Difficile Vaccine Safety, Tolerability, and Immunogenicity Study in Japanese Adults (PHASE1)

Primary sources

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