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buspirone+alprazolam
This combination pairs a serotonin 5-HT1A receptor agonist (buspirone) with a benzodiazepine GABA-A receptor agonist (alprazolam) to enhance anxiolytic effects through dual pathways.
This combination pairs a serotonin 5-HT1A receptor agonist (buspirone) with a benzodiazepine GABA-A receptor agonist (alprazolam) to enhance anxiolytic effects through dual pathways. Used for Anxiety disorders (generalized anxiety disorder, panic disorder), Short-term anxiety management.
At a glance
| Generic name | buspirone+alprazolam |
|---|---|
| Sponsor | Seoul National University Hospital |
| Drug class | Anxiolytic combination (azapirone + benzodiazepine) |
| Target | 5-HT1A receptor (buspirone); GABA-A receptor (alprazolam) |
| Modality | Small molecule |
| Therapeutic area | Psychiatry / Neurology |
| Phase | FDA-approved |
Mechanism of action
Buspirone selectively binds to serotonin 5-HT1A receptors, modulating serotonergic neurotransmission to reduce anxiety without sedation or muscle relaxation. Alprazolam enhances GABAergic inhibitory neurotransmission by potentiating GABA-A receptors, producing rapid anxiolytic, sedative, and muscle-relaxant effects. The combination leverages both mechanisms for broader anxiety symptom coverage.
Approved indications
- Anxiety disorders (generalized anxiety disorder, panic disorder)
- Short-term anxiety management
Common side effects
- Dizziness
- Drowsiness/sedation
- Headache
- Dependence/withdrawal risk (alprazolam component)
- Cognitive impairment
Key clinical trials
- Pharmacovigilance in Gerontopsychiatric Patients (PHASE3)
- Effects of Buspar on Depressive Symptom Improvement and Neuroprotection in Patients With Anxiety Disorder (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- buspirone+alprazolam CI brief — competitive landscape report
- buspirone+alprazolam updates RSS · CI watch RSS
- Seoul National University Hospital portfolio CI