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Bupropion Sustained Release
Norepinephrine-dopamine reuptake inhibitor
Norepinephrine-dopamine reuptake inhibitor Used for Major depressive disorder, Seasonal affective disorder.
At a glance
| Generic name | Bupropion Sustained Release |
|---|---|
| Also known as | Zyban, Zyban, Wellbutrin |
| Sponsor | Iowa City Veterans Affairs Medical Center |
| Drug class | Norepinephrine-dopamine reuptake inhibitor |
| Modality | Small molecule |
| Therapeutic area | Neurology |
| Phase | Phase 2 |
Mechanism of action
Bupropion works by inhibiting the reuptake of norepinephrine and dopamine in the brain, increasing their levels and activity.
Approved indications
- Major depressive disorder
- Seasonal affective disorder
Common side effects
- Insomnia
- Dry mouth
- Headache
Key clinical trials
- A Trial of Dextromethorphan and Bupropion Sustained-Release Tablets in Patients With Major Depressive Disorder (PHASE3)
- Reward-specific Changes of the Chemical Messenger Dopamine in the Brain of Healthy and Depressed People (PHASE4)
- Behavioral and Pharmacologic Treatment of Binge Eating and Obesity: Maintenance Therapy (PHASE2, PHASE3)
- Bupropion in the Treatment of Methamphetamine Dependence (NA)
- Behavioral and Pharmacologic Treatment of Binge Eating and Obesity: Acute Treatment (PHASE2, PHASE3)
- AXS-05 Phase II Trial on Smoking Behavior (PHASE2)
- Study In Patients With Depression Not Responding to Selective Serotonin Re-uptake Inhibitors (PHASE3)
- Tailored Tobacco Quitline for Rural Veterans (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Bupropion Sustained Release CI brief — competitive landscape report
- Bupropion Sustained Release updates RSS · CI watch RSS
- Iowa City Veterans Affairs Medical Center portfolio CI