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Buprenorphine Transdermal Matrix Patch
Buprenorphine is a partial mu-opioid receptor agonist that binds with high affinity to opioid receptors in the central nervous system to provide analgesia and reduce opioid cravings.
Buprenorphine is a partial mu-opioid receptor agonist that binds with high affinity to opioid receptors in the central nervous system to provide analgesia and reduce opioid cravings. Used for Chronic pain management, Opioid use disorder maintenance treatment.
At a glance
| Generic name | Buprenorphine Transdermal Matrix Patch |
|---|---|
| Sponsor | Washington University School of Medicine |
| Drug class | Partial mu-opioid receptor agonist |
| Target | Mu-opioid receptor (μ-OR) |
| Modality | Small molecule |
| Therapeutic area | Pain Management; Opioid Use Disorder |
| Phase | Phase 3 |
Mechanism of action
Buprenorphine's partial agonist activity at the mu-opioid receptor produces a ceiling effect on respiratory depression, making it safer than full opioid agonists. The transdermal matrix patch formulation provides sustained, controlled release of buprenorphine through the skin, enabling prolonged dosing intervals and improved patient compliance compared to oral or sublingual formulations.
Approved indications
- Chronic pain management
- Opioid use disorder maintenance treatment
Common side effects
- Application site reactions
- Headache
- Nausea
- Dizziness
- Constipation
- Respiratory depression
Key clinical trials
- ACTION: Trial of Adding Buprenorphine, CBT, and TMS to Improve Outcomes of Long-Term Opioid Therapy for Chronic Pain (PHASE1, PHASE2)
- Transdermal Patch for BupRenorphine Induction DurinG PrEgnancy (Patch BRIDGE) (PHASE3)
- Buprenorphine as a Post-operative Analgesic in Opioid-Naive Patients After Ankle Fracture Surgery (PHASE4)
- Transdermal Buprenorphine for the Treatment of Radiation-Induced Mucositis Pain in Head and Neck Cancer Patients (PHASE2)
- Transdermal Buprenorphine Patch for Laparoscopic Cholecystectomy (NA)
- Neuroimaging Study on the Effect of Transdermal Buprenorphine in Complex Regional Pain Syndrome Patients
- Role of Preoperative Transdermal Buprenorphine Patch in Reducing Postoperative Opioids Consumption in Patients Undergoing Total Knee Arthroplasties - A Randomised Controlled Trial. (PHASE4)
- Safety and Effectiveness of Transdermal Buprenorphine in Cancer Pain
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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