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Bupivicaine + epinephrine
Bupivacaine blocks sodium channels in nerve cell membranes to produce local anesthesia, while epinephrine causes vasoconstriction to prolong the anesthetic effect and reduce systemic absorption.
Bupivacaine blocks sodium channels in nerve cell membranes to produce local anesthesia, while epinephrine causes vasoconstriction to prolong the anesthetic effect and reduce systemic absorption. Used for Local and regional anesthesia for surgical, dental, and pain management procedures.
At a glance
| Generic name | Bupivicaine + epinephrine |
|---|---|
| Sponsor | Rush University Medical Center |
| Drug class | Local anesthetic with vasopressor |
| Target | Voltage-gated sodium channels; alpha and beta-adrenergic receptors |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Bupivacaine is a long-acting amide local anesthetic that reversibly inhibits sodium influx into nerve fibers, preventing depolarization and conduction of nerve impulses. Epinephrine, an alpha and beta-adrenergic agonist, causes vasoconstriction of local blood vessels, which slows the systemic absorption of bupivacaine, extends its duration of action, and reduces the risk of systemic toxicity.
Approved indications
- Local and regional anesthesia for surgical, dental, and pain management procedures
Common side effects
- Injection site reactions (pain, erythema)
- Transient paresthesia
- Headache
- Dizziness
- Systemic toxicity (CNS and cardiac effects at high doses)
Key clinical trials
- Total Knee Arthroplasty Infiltration Study for Postoperative Analgesia (PHASE2)
- Exparel Versus Bupivacaine in Post-operative Pain Control (PHASE4)
- Analgesic Efficacy of Anterior Femoral, Genicular and Adductor Canal Nerve Block (NA)
- The PAIN (Pelvic Area Injection for Numbness) Study (PHASE4)
- Effect of Post-Operative Anesthetics on Post-Operative Pain in Patients Receiving Endodontic Treatment (PHASE4)
- Intraperitoneal Bupivacaine for Pelvic Organ Prolapse (PHASE4)
- Bilateral TAP and RS Blocks Using Liposomal Bupivacaine/Bupivacaine vs. Regular Bupivacaine in Laparoscopic Colectomy (PHASE4)
- RCT Comparing ESPB Solutions in Breast Surgery (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Bupivicaine + epinephrine CI brief — competitive landscape report
- Bupivicaine + epinephrine updates RSS · CI watch RSS
- Rush University Medical Center portfolio CI