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bupivacaine with hydromorphone
bupivacaine with hydromorphone is a Local anesthetic and opioid analgesic combination Small molecule drug developed by University of Virginia. It is currently in Phase 3 development for Postoperative pain management, Pain management during medical procedures.
Bupivacaine with hydromorphone is a combination of a local anesthetic and an opioid analgesic that works by blocking nerve signals in the body and providing pain relief.
Bupivacaine with hydromorphone is a combination of a local anesthetic and an opioid analgesic that works by blocking nerve signals in the body and providing pain relief. Used for Postoperative pain management, Pain management during medical procedures.
At a glance
| Generic name | bupivacaine with hydromorphone |
|---|---|
| Sponsor | University of Virginia |
| Drug class | Local anesthetic and opioid analgesic combination |
| Modality | Small molecule |
| Therapeutic area | Pain management |
| Phase | Phase 3 |
Mechanism of action
Bupivacaine is a long-acting local anesthetic that blocks sodium channels in nerve cells, preventing the initiation and transmission of nerve impulses. Hydromorphone, an opioid analgesic, binds to opioid receptors in the brain and spinal cord, producing analgesia and sedation.
Approved indications
- Postoperative pain management
- Pain management during medical procedures
Common side effects
- Nausea
- Vomiting
- Dizziness
- Headache
- Drowsiness
Key clinical trials
- Intrathecal Hydromorphone vs Intrathecal Morphine to Treat Post Cesarean Pain in Patients With Opioid Use Disorder Taking Buprenorphine (PHASE4)
- Spinal Anesthesia For Enhanced Recovery After Liver Surgery (NA)
- Rectus Sheath Block With Liposomal Bupivacaine Versus Thoracic Epidural Analgesia for Pain Control Following Pancreatoduodenectomy (PHASE2)
- Rectus Sheath Block for Analgesia After Gynecological Laparotomy (PHASE4)
- Pectoralis and Serratus Muscle Blocks (PHASE4)
- Multimodal Analgesia Effect on Post Surgical Patient (PHASE4)
- Comparing Intrathecal Morphine and Intraoperative Lidocaine Infusion to Epidural Anesthesia With Postoperative PCA for Patients Undergoing Exploratory Laparotomy (PHASE2)
- IV vs Epidural Opioids + Epidural Local Anesthetic for Laparotomy Analgesia (PHASE2, PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- bupivacaine with hydromorphone CI brief — competitive landscape report
- bupivacaine with hydromorphone updates RSS · CI watch RSS
- University of Virginia portfolio CI
Frequently asked questions about bupivacaine with hydromorphone
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Related
- Drug class: All Local anesthetic and opioid analgesic combination drugs
- Manufacturer: University of Virginia — full pipeline
- Therapeutic area: All drugs in Pain management
- Indication: Drugs for Postoperative pain management
- Indication: Drugs for Pain management during medical procedures
- Compare: bupivacaine with hydromorphone vs similar drugs
- Pricing: bupivacaine with hydromorphone cost, discount & access