Last reviewed · How we verify
Bupivacaine heavy and Morphine
Bupivacaine heavy (hyperbaric) provides local anesthesia via sodium channel blockade, while morphine provides opioid analgesia via mu-receptor agonism, used together for intrathecal spinal anesthesia and analgesia.
Bupivacaine heavy (hyperbaric) provides local anesthesia via sodium channel blockade, while morphine provides opioid analgesia via mu-receptor agonism, used together for intrathecal spinal anesthesia and analgesia. Used for Intrathecal spinal anesthesia and analgesia for surgical procedures, Postoperative pain management.
At a glance
| Generic name | Bupivacaine heavy and Morphine |
|---|---|
| Sponsor | Post Graduate Institute of Medical Education and Research, Chandigarh |
| Drug class | Local anesthetic + opioid combination |
| Target | Voltage-gated sodium channels (bupivacaine); mu-opioid receptor (morphine) |
| Modality | Small molecule |
| Therapeutic area | Anesthesiology / Pain Management |
| Phase | FDA-approved |
Mechanism of action
Bupivacaine heavy is a long-acting local anesthetic that blocks sodium channels in nerve fibers, preventing action potential propagation and producing reversible sensory and motor blockade. Morphine is a mu-opioid receptor agonist that enhances analgesia and provides prolonged postoperative pain relief when administered intrathecally. The combination leverages synergistic effects for comprehensive perioperative anesthesia and analgesia.
Approved indications
- Intrathecal spinal anesthesia and analgesia for surgical procedures
- Postoperative pain management
Common side effects
- Hypotension
- Bradycardia
- Respiratory depression
- Urinary retention
- Pruritus
- Nausea and vomiting
- Headache
Key clinical trials
- Pericapsular Nerve Group Block Versus Intrathecal Morphine for Analgesia After Total Hip Arthroplasty (NA)
- Spinal Anesthesia For Enhanced Recovery After Liver Surgery (NA)
- Saddle Block With IT Morphine for Penile Inversion Vaginoplasty (NA)
- Comparing Pericapsular Nerve Group Block with Lumbar Erector Spinae Plain Block in Total Hip Arthroplasty Surgery (NA)
- Analgesic Efficacy of Intrathecal Fentanyl-Morphine Combination Versus Morphine Alone for Intraoperative Pain During Elective Cesarean Delivery (PHASE4)
- GENERAL vs. REGIONAL ANESTHESIA ON SLEEP QUALITY FOR HIP ARTROPLASTY PATIENTS (NA)
- Respiratory Rate After Cesarean Delivery
- Impact of Adductor Canal Block on Functional Recovery (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape: