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Bupivacaine-fentanyl emergency group
Bupivacaine provides local anesthesia by blocking sodium channels in nerve fibers, while fentanyl provides opioid analgesia by binding to mu opioid receptors.
Bupivacaine provides local anesthesia by blocking sodium channels in nerve fibers, while fentanyl provides opioid analgesia by binding to mu opioid receptors. Used for Emergency anesthesia and analgesia, Acute pain management in emergency settings.
At a glance
| Generic name | Bupivacaine-fentanyl emergency group |
|---|---|
| Sponsor | Conrad Arnfinn Bjørshol |
| Drug class | Local anesthetic + opioid analgesic combination |
| Target | Voltage-gated sodium channels (bupivacaine); mu opioid receptor (fentanyl) |
| Modality | Small molecule |
| Therapeutic area | Anesthesia, Emergency Medicine, Pain Management |
| Phase | FDA-approved |
Mechanism of action
Bupivacaine is a long-acting local anesthetic that inhibits sodium influx into nerve cells, preventing depolarization and blocking pain signal transmission. Fentanyl is a potent synthetic opioid agonist that binds to mu opioid receptors in the central and peripheral nervous system to produce analgesia and sedation. This combination is used in emergency settings to provide rapid onset local anesthesia with concurrent systemic pain relief.
Approved indications
- Emergency anesthesia and analgesia
- Acute pain management in emergency settings
Common side effects
- Hypotension
- Respiratory depression
- Bradycardia
- Nausea
- Local anesthetic toxicity (at high doses)
Key clinical trials
- Comparison of the Efficiency of Femur Nerve Block and Intravenous Analgesia Treatment in Hip Fracture Patients (PHASE4)
- Delirium in Elderly Patients With Trauma of the Hip (PHASE4)
- Postoperative Pain After Caesarian Section (PHASE4)
- Effect of Local Anesthesia Versus Induced Hypotensive Anesthesia on Quality of External Dacryocystorhinostomy Operation (NA)
- Does the Mode of Anesthesia Affect the Feto-maternal Outcome in Category-1 Caesarean Section
- Serratus Anterior Plane Block Versus Thoracic Paravertebral Block. (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Bupivacaine-fentanyl emergency group CI brief — competitive landscape report
- Bupivacaine-fentanyl emergency group updates RSS · CI watch RSS
- Conrad Arnfinn Bjørshol portfolio CI