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Bupivacaine(B)
Bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials.
Bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials. Used for Local anesthesia for infiltration, nerve block, epidural, and spinal anesthesia, Pain management in surgical and dental procedures.
At a glance
| Generic name | Bupivacaine(B) |
|---|---|
| Sponsor | Huazhong University of Science and Technology |
| Drug class | Local anesthetic (amide) |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Bupivacaine reversibly binds to and inactivates voltage-gated sodium channels on the inner surface of nerve cell membranes, thereby preventing depolarization and conduction of nerve impulses. This results in local anesthesia of the area where it is administered. It is a long-acting amide-type local anesthetic with a relatively slow onset but prolonged duration of action compared to other local anesthetics.
Approved indications
- Local anesthesia for infiltration, nerve block, epidural, and spinal anesthesia
- Pain management in surgical and dental procedures
Common side effects
- Hypotension
- Bradycardia
- Dizziness
- Nervousness
- Systemic toxicity (CNS and cardiac effects at high doses)
Key clinical trials
- Continuous Epidural With Dexmedetomidine Adjuvant in Gynecologic Laparotomy (PHASE4)
- Erector Spinae Plane Versus Quadratus Lumborum Blocks for Pain Management After Total Abdominal Hysterectomy (NA)
- Bupivacaine Liposome Plus Bupivacaine or Ropivacaine for Pericapsular Nerve Group Block in Hip Arthroplasty (PENG) (PHASE4)
- Ketamine, SGB and Combination Treatment for TBI (PHASE2)
- Intrathecal Bupivacaine With or Without Dexmetomidine for Cesserian Delivery (PHASE2)
- Comparison of Mean Duration of Analgesia Following the Administration of Bupivacaine With and Without Magnesium Sulphate in Ultrasound Guided Erector Spinae Plane Block in Modified Radical Mastectomy Patients (NA)
- EXPAREL or Lidocane as Local Anesthetic in Patients Undergoing Pleuroscopy With Pleural Biopsy and Indwelling Pleural Catheter Placement (PHASE2)
- Evaluation of Supraclavicular Brachial Plexus Blocks at Various Volumes: Impact on Optic Nerve Sheath Diameter (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |