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Bupivacaine and Dexamethasone Injection
Bupivacaine provides local anesthesia by blocking sodium channels in nerve fibers, while dexamethasone reduces inflammation and swelling at the injection site.
Bupivacaine provides local anesthesia by blocking sodium channels in nerve fibers, while dexamethasone reduces inflammation and swelling at the injection site. Used for Local and regional anesthesia with anti-inflammatory adjuvant therapy, Nerve blocks and infiltration anesthesia.
At a glance
| Generic name | Bupivacaine and Dexamethasone Injection |
|---|---|
| Also known as | Decadron, bupivacaine |
| Sponsor | Colette Curtis MD |
| Drug class | Local anesthetic with corticosteroid adjuvant |
| Target | Voltage-gated sodium channels (bupivacaine); glucocorticoid receptor (dexamethasone) |
| Modality | Small molecule |
| Therapeutic area | Pain Management / Regional Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Bupivacaine is a long-acting local anesthetic that inhibits sodium influx into nerve cells, preventing depolarization and blocking pain signal transmission. Dexamethasone, a corticosteroid, suppresses inflammatory responses and reduces edema, potentially prolonging anesthetic duration and improving pain relief. This combination is used to enhance and extend the analgesic effect of local anesthesia.
Approved indications
- Local and regional anesthesia with anti-inflammatory adjuvant therapy
- Nerve blocks and infiltration anesthesia
Common side effects
- Injection site pain or discomfort
- Transient numbness or paresthesia
- Systemic toxicity from local anesthetic (rare)
- Allergic reaction
Key clinical trials
- Arthrosemid vs. Steroid for the Management Knee Osteoarthritis (PHASE4)
- Comparison of Intrathecal Morphine and Rectus Sheath Block for Postoperative Pain Management After Lower Abdominal Surgery With Midline Incision (NA)
- Comparison Between Dexamethasone and Dexmedetomidine in Spinal Anesthesia for Cases With Fracture Pelvis Fixation (EARLY_PHASE1)
- Postoperative Pain Monitoring With ANI in Lumbar Spine Surgery (NA)
- Pericapsular Nerve Group Block Versus Intrathecal Morphine for Analgesia After Total Hip Arthroplasty (NA)
- Thoracic Epidural Analgesia With Bilateral Erector Spinae Plane Block in Radical Cystectomy Surgery (NA)
- ESP Block VS Intrathecal Opioid After Laparoscopic Colorectal Surgery (PHASE1, PHASE2)
- Prospective Evaluation of Efficacy of Tumescent Steroid Infiltration in Mandibular Third Molar Surgery: a Split Mouth Randomized Study (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Bupivacaine and Dexamethasone Injection CI brief — competitive landscape report
- Bupivacaine and Dexamethasone Injection updates RSS · CI watch RSS
- Colette Curtis MD portfolio CI