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Bupivacaine 0.5 % with Epinephrine
Bupivacaine blocks sodium channels in nerve cell membranes to produce local anesthesia, while epinephrine causes vasoconstriction to prolong the anesthetic effect and reduce systemic absorption.
Bupivacaine blocks sodium channels in nerve cell membranes to produce local anesthesia, while epinephrine causes vasoconstriction to prolong the anesthetic effect and reduce systemic absorption. Used for Local and regional anesthesia for surgical procedures, Infiltration anesthesia, Nerve blocks.
At a glance
| Generic name | Bupivacaine 0.5 % with Epinephrine |
|---|---|
| Sponsor | Holy Cross Hospital, Florida |
| Drug class | Local anesthetic with vasopressor |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Bupivacaine is a long-acting amide local anesthetic that reversibly inhibits sodium influx into nerve fibers, preventing depolarization and conduction of nerve impulses. The addition of epinephrine (adrenaline) causes vasoconstriction of local blood vessels, which slows the systemic absorption of bupivacaine, extends its duration of action at the injection site, and reduces the risk of systemic toxicity.
Approved indications
- Local and regional anesthesia for surgical procedures
- Infiltration anesthesia
- Nerve blocks
- Epidural anesthesia
Common side effects
- Nervousness, anxiety
- Dizziness, lightheadedness
- Tinnitus
- Tremor
- Cardiac arrhythmias (with systemic absorption)
- Hypotension
- Allergic reactions (rare with amides)
Key clinical trials
- Postop Pain Management in Pituitary Tumour Patients (PHASE4)
- Genicular Nerve Block for Knee Pain in the ED (NA)
- Efficacy of Intercostal CryoAnalgesia in Robotic Lung Resection (PHASE4)
- Functional Endoscopic Sinus Surgery Study (PHASE1, PHASE2)
- Dose-Finding Study: MEV90 for Local Anesthetic in Interscalene Block for Supraclavicular Nerves Block (NA)
- Effect of Reparel Knee Sleeve With Knee Injection (NA)
- Interscalene Block Versus Combined Infraclavicular-Anterior Suprascapular Blocks for Shoulder Surgery (NA)
- ESP vs SPSIP Block in VATS Analgesia (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Bupivacaine 0.5 % with Epinephrine CI brief — competitive landscape report
- Bupivacaine 0.5 % with Epinephrine updates RSS · CI watch RSS
- Holy Cross Hospital, Florida portfolio CI