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Budesonide / Formoterol 400/12
Budesonide / Formoterol 400/12 is a Inhaled corticosteroid / long-acting beta-2 agonist combination Small molecule drug developed by EMS. It is currently in Phase 3 development for Asthma maintenance therapy, Chronic obstructive pulmonary disease (COPD) maintenance therapy.
Budesonide reduces airway inflammation via glucocorticoid receptor activation, while formoterol dilates airways by stimulating beta-2 adrenergic receptors.
Budesonide reduces airway inflammation via glucocorticoid receptor activation, while formoterol dilates airways by stimulating beta-2 adrenergic receptors. Used for Asthma maintenance therapy, Chronic obstructive pulmonary disease (COPD) maintenance therapy.
At a glance
| Generic name | Budesonide / Formoterol 400/12 |
|---|---|
| Sponsor | EMS |
| Drug class | Inhaled corticosteroid / long-acting beta-2 agonist combination |
| Target | Glucocorticoid receptor; beta-2 adrenergic receptor |
| Modality | Small molecule |
| Therapeutic area | Respiratory / Pulmonology |
| Phase | Phase 3 |
Mechanism of action
Budesonide is an inhaled corticosteroid that suppresses inflammatory mediators and immune cell recruitment in the lungs. Formoterol is a long-acting beta-2 agonist that relaxes bronchial smooth muscle, improving airflow. Together, they provide both anti-inflammatory and bronchodilatory effects for sustained asthma and COPD control.
Approved indications
- Asthma maintenance therapy
- Chronic obstructive pulmonary disease (COPD) maintenance therapy
Common side effects
- Tremor
- Headache
- Palpitations
- Oral candidiasis
- Nervousness
Key clinical trials
- Pressurized Meter Dose Inhaler V/S Dry Powder Inhaler (NA)
- A Non-inferiority, Comparative Study Between Foraseq®, Eurofarma´s Formoterol/Budesonide and Alenia® in Asthma (PHASE3)
- A Study to Assess the Reduction of Daily Maintenance ICS/LABA Treatment Towards Anti-Inflammatory Reliever Treatment in Patients With Severe Eosinophilic Asthma Treated With Benralizumab (PHASE4)
- Study to Evaluate the Mastery of Inhaler Technique for Budesonide Formoterol (BF) SPIROMAX® as Compared to SYMBICORT® TURBOHALER® as Treatment for Adult Participants With Asthma (PHASE3)
- Efficacy and Safety of Flamboyant 200/12 Association in the Treatment of Adults With Severe Asthma (PHASE3)
- Microbiome Use to Stratify Use of Inhaled Corticosteroids: MUSIC Trial (PHASE4)
- Assessment of Bronchodilator Efficacy of Formoterol/Budesonide 12/400 mcg Via Discair in COPD (PHASE4)
- A Study to Investigate the Differential Effects of Inhaled Symbicort and Advair on Lung Microbiota (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Budesonide / Formoterol 400/12 CI brief — competitive landscape report
- Budesonide / Formoterol 400/12 updates RSS · CI watch RSS
- EMS portfolio CI
Frequently asked questions about Budesonide / Formoterol 400/12
What is Budesonide / Formoterol 400/12?
How does Budesonide / Formoterol 400/12 work?
What is Budesonide / Formoterol 400/12 used for?
Who makes Budesonide / Formoterol 400/12?
What drug class is Budesonide / Formoterol 400/12 in?
What development phase is Budesonide / Formoterol 400/12 in?
What are the side effects of Budesonide / Formoterol 400/12?
What does Budesonide / Formoterol 400/12 target?
Related
- Drug class: All Inhaled corticosteroid / long-acting beta-2 agonist combination drugs
- Target: All drugs targeting Glucocorticoid receptor; beta-2 adrenergic receptor
- Manufacturer: EMS — full pipeline
- Therapeutic area: All drugs in Respiratory / Pulmonology
- Indication: Drugs for Asthma maintenance therapy
- Indication: Drugs for Chronic obstructive pulmonary disease (COPD) maintenance therapy
- Compare: Budesonide / Formoterol 400/12 vs similar drugs
- Pricing: Budesonide / Formoterol 400/12 cost, discount & access