Last reviewed 2026-04-20 · How we verify

Durazanil (BROMAZEPAM)

Durazanil works by enhancing the activity of the neurotransmitter GABA, which helps to calm excessive brain activity.

Durazanil, also known as bromazepam, is a small molecule drug that targets the GABA-A receptor alpha-1/beta-2/gamma-2 subunits. It is a benzodiazepine class medication, but its commercial status is unknown. Durazanil is not FDA-approved, and its approved indications are also unknown. The medication has a half-life of 21.0 hours and a bioavailability of 84%. Key safety considerations include its potential for dependence and abuse.

At a glance

Mechanism of action

Imagine your brain is like a busy city with lots of noise and activity. GABA is like a traffic cop that helps to slow down the traffic and keep things calm. Durazanil helps the traffic cop do its job more effectively, which can help to reduce anxiety and promote relaxation.

Approved indications

No approved indications tracked.

Common side effects

• Coma
• Drug abuse
• Poisoning deliberate
• Sopor
• Toxicity to various agents
• Somnolence
• Suicide attempt
• Mydriasis
• Drug dependence
• Drug use disorder
• Altered state of consciousness
• Miosis

Key clinical trials

• The Combination of Pharmacotherapy and Cognitive Behavioral Psychotherapy Under the Recovery Perspective. (PHASE1)
• Home Detox in Medication Overuse Headache (MOH) During Covid-19 Emergency (PHASE4)
• Virtual Reality for Pain Management and Patient Satisfaction During Outpatient Hysteroscopy (NA)
• Pharmacovigilance in Gerontopsychiatric Patients (PHASE3)
• Study of Trimebutine Maleate (NEWBUTIN SR 300 mg Tab)for Treatment of Post Operative Nausea and Vomiting (PHASE3)

Primary sources

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