Last reviewed · How we verify
Brevibloc
At a glance
| Generic name | Brevibloc |
|---|---|
| Also known as | Esmolol |
| Sponsor | AOP Orphan Pharmaceuticals AG |
| Target | Beta-1 adrenergic receptor, Beta-1 adrenergic receptor, Beta-2 adrenergic receptor |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular |
| Phase | FDA-approved |
Approved indications
- Atrial fibrillation
- Perioperative Tachycardia
- Perioperative hypertension
- Supraventricular tachycardia
Common side effects
- Asymptomatic hypotension
- Symptomatic hypotension (hyperhidrosis, dizziness)
- Infusion site reactions (inflammation and induration)
- Nausea
- Dizziness
- Somnolence
- Confusional state and agitation
- Headache
- Vomiting
- Peripheral ischemia
Serious adverse events
- Cardiac arrest
- Coronary arteriospasm
- Convulsions with death
- Angioedema
- Syncope
Key clinical trials
- Opioid Free and Opioid Based Anesthesia in Elective Lumbar Spine Surgery
- POCUS-Guided Esmolol in Septic Shock: A Pilot RCT (PHASE1, PHASE2)
- Effect of MGRNOX-Guided General Anesthesia on Opioid Consumption in Patients (NA)
- Esmolol Versus Sufentanil on the Quality of Post-cholecystectomy Recovery Laparoscopic Anaesthesia With Orotracheal Intubation on an Outpatient Basis (PHASE4)
- Reduction of Edema With a Specialized Cocktail for Ultra-early Management in Intracerebral Hemorrhage (PHASE3)
- Age Comparisons of Exercising Muscle O2 Supply in Healthy Adults: Effects of Esmolol Infusion (EARLY_PHASE1)
- Opioids Continue to Play a Primary Role in the Management of Perioperative Pain Due to Opioid-Free Anesthesia in Open Heart Surgery.
- Effect of Opioid-free Anaesthesia on Postoperative Delirium in Elderly Patients Undergoing Gastrointestinal Surgery (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |