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botulinum toxin intramuscular injection
Botulinum toxin works by blocking the release of acetylcholine, a neurotransmitter that transmits nerve impulses, thereby reducing muscle spasms and contractions.
Botulinum toxin works by blocking the release of acetylcholine, a neurotransmitter that transmits nerve impulses, thereby reducing muscle spasms and contractions. Used for Treatment of blepharospasm, hemifacial spasm, and strabismus, Treatment of cervical dystonia, Treatment of axillary hyperhidrosis.
At a glance
| Generic name | botulinum toxin intramuscular injection |
|---|---|
| Also known as | Botox, Allergan. |
| Sponsor | Guy's and St Thomas' NHS Foundation Trust |
| Drug class | Neuromuscular blocker |
| Target | SNARE complex |
| Modality | Small molecule |
| Therapeutic area | Neurology |
| Phase | Phase 3 |
Mechanism of action
This is achieved by cleaving the SNARE complex, which is essential for the release of acetylcholine from the presynaptic neuron. As a result, muscle contractions are reduced, leading to a decrease in muscle spasms and contractions.
Approved indications
- Treatment of blepharospasm, hemifacial spasm, and strabismus
- Treatment of cervical dystonia
- Treatment of axillary hyperhidrosis
- Treatment of facial wrinkles and frown lines
- Treatment of migraines
- Treatment of overactive bladder
Common side effects
- Dry mouth
- Headache
- Eyelid swelling
- Drooping eyelid
- Muscle weakness
- Nausea
- Fatigue
- Dizziness
- Pain
- Injection site reaction
Key clinical trials
- A Study to Evaluate Patient Satisfaction With the Overall Face and Neck Appearance After Combined Treatment of OnabotulinumtoxinA, JUVÉDERM® Products, KYBELLA, CoolSculpting Elite and SkinMedica Products (PHASE4)
- Study to Compare the Efficacy and Safety of NT 201 (Botulinum Toxin) With Placebo for the Treatment of Lower Limb Spasticity Caused by Stroke or Traumatic Brain Injury (PHASE3)
- Effectiveness and Safety of Early Intramuscular Botulinum Toxin Injections to Prevent Shoulder Deformity in Babies With Obstetrical Brachial Plexus Palsy (PHASE3)
- Upper Limb Nerve Cryoneurolysis is Non Inferior to the Usual Care and Has Therapeutic Add Value in Dealing With Shoulder Pain and Functional Problems Caused by Spasticity and Motor Impairment (NA)
- A Study on Recombinant Botulinum Toxin Type A (YY001) for Injection in Multiple Treatments of Adult Upper Limb Spasticity (PHASE3)
- A Study of NT 201 in Adults With Moderate to Severe Platysma Prominence in Europe (PLATINUM EU) (PHASE3)
- A Study to Evaluate the Effectiveness and Safety of Dysport® for the Prevention of Episodic Migraine in Adults (PHASE3)
- A Study to Evaluate the Effectiveness and Safety of Dysport® for the Prevention of Chronic Migraine in Adults (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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