Last reviewed · How we verify
Botox infiltration
Botulinum toxin blocks acetylcholine release at the neuromuscular junction, causing temporary paralysis of injected muscles.
Botulinum toxin blocks acetylcholine release at the neuromuscular junction, causing temporary paralysis of injected muscles. Used for Muscle hyperactivity disorders (cervical dystonia, blepharospasm, hemifacial spasm), Chronic migraine, Spasticity.
At a glance
| Generic name | Botox infiltration |
|---|---|
| Also known as | botox infiltration, and grup solving terapy group |
| Sponsor | University Rovira i Virgili |
| Drug class | Neurotoxin; botulinum toxin type A |
| Target | SNARE complex (synaptosome-associated protein); acetylcholine release machinery |
| Modality | Small molecule |
| Therapeutic area | Neurology; Dermatology; Aesthetics |
| Phase | FDA-approved |
Mechanism of action
Botox (botulinum toxin type A) cleaves SNARE proteins required for acetylcholine vesicle release, preventing muscle contraction in the infiltrated area. This results in temporary muscle relaxation lasting 3-4 months. The effect is localized to the injection site and gradually reverses as new neuromuscular junctions form.
Approved indications
- Muscle hyperactivity disorders (cervical dystonia, blepharospasm, hemifacial spasm)
- Chronic migraine
- Spasticity
- Cosmetic wrinkle reduction (glabellar lines, crow's feet, forehead lines)
Common side effects
- Injection site pain or bruising
- Headache
- Muscle weakness or paralysis (unintended muscles)
- Ptosis (eyelid drooping)
- Dry mouth or dry eye
- Flu-like symptoms
Key clinical trials
- Effect of Botulinum Toxin Type A on Motor Function in Children With Cerebral Palsy (NA)
- Pretreatment Botulinum Toxin in Head and Neck Cancer Surgery (PHASE2)
- Botulinum Toxin for Chronic Neuropathic Pain
- Botulinum Toxin in Patients With Spastic Lower Limb Paresis Associated With Multiple Sclerosis (PHASE3)
- Valuation of the Evolution of Passive Mobility in the Spastic Upper Limb After Injection of Abobotulinumtoxin(Dysport®)
- Botulinum Toxin Type A Block of the Sphenopalatine Ganglion in Chronic Rhinosinusitis With Nasal Polyposis (PHASE2)
- Management of Popeye Sign With Botulinum Toxin After Bicepstenotomy (PHASE4)
- Therapeutic Effect of Botulinum Toxin A for the Treatment of Plantar Fasciitis. (PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |