Last reviewed 2026-04-22 · How we verify

Bone marrow aspirate matrix

Bone marrow aspirate matrix is a cellular therapy product containing bone marrow-derived stem cells and growth factors that promote tissue regeneration and repair.

Bone marrow aspirate matrix is a cellular therapy product containing bone marrow-derived stem cells and growth factors that promote tissue regeneration and repair. Used for Bone defects and fracture healing, Cartilage and joint repair.

At a glance

Mechanism of action

This product harnesses the regenerative potential of autologous bone marrow cells, including mesenchymal stem cells and hematopoietic progenitors, along with their secreted bioactive factors. These cells and factors stimulate angiogenesis, reduce inflammation, and promote differentiation into tissue-specific cell types to facilitate healing of damaged bone and cartilage.

Approved indications

• Bone defects and fracture healing
• Cartilage and joint repair

Common side effects

• Injection site pain or swelling
• Infection at harvest or injection site
• Hematoma

Key clinical trials

• Allograft vs. Autograft Nonunion (NA)
• Post Marketing Study of MagnetOs Easypack Putty Standalone Compared to Demineralized Bone Matrix or Fibers Mixed With Autograft in Patients Undergoing Posterolateral Lumbar Fusion (NA)
• FIBERGRAFT Aeridyan Posterolateral Fusion Study (NA)
• Prospective, Multi-center Study to Assess Posterolateral Fusion Using FIBERGRAFT (NA)
• BMAC Loaded Collagen Jumping the Gap Around Immediate Implants (NA)
• Return to Play After ACL Reconstruction With Bone Marrow Aspirate, DBM, and an Internal Brace
• Bio ACL Reconstruction Amnion Collagen Matrix Wrap and Stem Cells (NA)
• Treatment of Knee Osteoarthritis With Bone Marrow Aspirate Matrix: Prospective, Randomized Trial (PHASE3)

Primary sources

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